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Showing 1–11 of 11 results
Advanced filters: Author: Michelle Krogsgaard Clear advanced filters

  • Neoantigen-specific T cells recognise neoantigen-MHC complexes on target tumour cells. Here, the authors describe a molecular mechanism by which the neoantigen Hsf2 p.K72N is recognised by a corresponding high affinity Hsf2 p.K72N-reactive T cell receptor, 47BE7, from the mouse melanoma line B16F10.

    • John P. Finnigan
    • Jenna H. Newman
    • Nina Bhardwaj
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Two methods for measuring cross-reactivity could boost the safety of T-cell therapies.

    • Aswin Natarajan
    • Michelle Krogsgaard
    News & Views
    Nature Biotechnology
    Volume: 36, P: 1152-1154

  • In this genomic analysis of peripheral blood samples of the phase 3 CheckMate-067 trial of ipilimumab (IPI) versus nivolumab (NIVO) versus ipilimumab and nivolumab (IPI-NIVO) in melanoma, the status of certain mitochondrial haplogroups in patients was associated therapeutic resistance to NIVO or IPI-NIVO, a finding validated in an independent cohort.

    • Kelsey R. Monson
    • Robert Ferguson
    • Tomas Kirchhoff
    ResearchOpen Access
    Nature Medicine
    Volume: 31, P: 2385-2396

  • Phosphorylated peptide antigens are present on cancer cells, but their role in cancer immunity is unknown. Here, the authors describe a molecular mechanism, by which a tumor-specific phosphopeptide found in acute myeloid leukemia is recognized by the human immune T cells.

    • Yury Patskovsky
    • Aswin Natarajan
    • Michelle Krogsgaard
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18

  • Catch bonds where lifetime increases with force applied can form when T cell receptors (TCR) interact with agonist peptide-MHC (pMHC) complexes. Here the authors use a modelling and experimental approach to analyse 55 TCR–pMHC bond lifetime curves measured under force to further characterise the structural bases and functional relevance of catch bonds.

    • Hyun-Kyu Choi
    • Peiwen Cong
    • Cheng Zhu
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-20

  • During immune responses, antibodies are selected for their ability to bind to foreign antigens with high affinity, in part by their ability to undergo homotypic bivalent binding. However, this type of binding is not always possible. Here, the monoclonal antibodies produced in two infected subjects in response to human immunodeficiency virus (HIV) glycoprotein have been analysed. The results provide evidence for polyreactivity, which may be required when the density of glycoprotein spikes is so low that bivalent binding is unlikely.

    • Hugo Mouquet
    • Johannes F. Scheid
    • Michel C. Nussenzweig
    Research
    Nature
    Volume: 467, P: 591-595