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Showing 1–6 of 6 results
Advanced filters: Author: Michelle Kushida Clear advanced filters

  • Previous work shows that a small population of quiescent SOX2+ medulloblastoma (MB) stem cells can drive tumour growth in early tumorigenesis and relapse. Here, the authors identify OLIG2 as a transcriptional mediator of the transition from quiescent to rapidly proliferating progenitor states and therapeutically target this axis in preclinical models of MB.

    • Kinjal Desai
    • Siyi Wanggou
    • Peter B. Dirks
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • Using unique barcodes for tumour cells, the authors explore the dynamics of human glioblastoma subpopulations, and suggest that clonal heterogeneity emerges through stochastic fate decisions of a neutral proliferative hierarchy.

    • Xiaoyang Lan
    • David J. Jörg
    • Peter B. Dirks
    Research
    Nature
    Volume: 549, P: 227-232

  • Pugh and colleagues use single-cell RNA sequencing, CRISPR screens and functional assays to define a gradient of developmental and wound-response cell states in glioblastoma stem cells, revealing insights into glioblastoma origins and potential therapeutic targets.

    • Laura M. Richards
    • Owen K. N. Whitley
    • Trevor J. Pugh
    Research
    Nature Cancer
    Volume: 2, P: 157-173

  • Triple negative breast cancer is a deadly form of breast cancer with limited therapeutic options. Here the authors show the efficacy of GLUT1 pharmacological inhibition against a subset of tumors expressing RB1, thereby identifying RB1 protein level as a biomarker of sensitivity to anti-GLUT1 therapy.

    • Qin Wu
    • Wail ba-alawi
    • Cheryl H. Arrowsmith
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • The arginine methyltransferase PRMT5 is over-expressed in cancer and has a role in the maintenance of stem cells. Here, the authors show that PRMT5 inhibitors can block the growth of patient derived glioblastoma stem cell cultures in vitro and in vivo, suggesting that PRMT5 inhibition may be a useful therapeutic strategy

    • Patty Sachamitr
    • Jolene C. Ho
    • Peter B. Dirks
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17