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Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy

Mark Chaffin
Irinna Papangeli
Patrick T. Ellinor
Research22 Jun 2022
Nature

Volume: 608, P: 174-180
Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations

The CPJUMP1 Resource comprises Cell Painting images and profiles of 75 million cells treated with hundreds of chemical and genetic perturbations. The dataset enables exploration of their relationships and lays the foundation for the development of advanced methods to match perturbations.

Srinivas Niranj Chandrasekaran
Beth A. Cimini
Anne E. Carpenter
ResearchOpen Access09 Apr 2024
Nature Methods

Volume: 21, P: 1114-1121
Optimizing the Cell Painting assay for image-based profiling

We provide an updated protocol for image-based profiling with Cell Painting. A detailed procedure, with standardized conditions for the assay, is presented, along with a comprehensive description of parameters to be considered when optimizing the assay.

Beth A. Cimini
Srinivas Niranj Chandrasekaran
Anne E. Carpenter
Protocols21 Jun 2023
Nature Protocols

Volume: 18, P: 1981-2013

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