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Showing 1–13 of 13 results

Advanced filters: Author: Michelle Pfeifer Clear advanced filters

Prospective, multicenter validation of a platform for rapid molecular profiling of central nervous system tumors

Application of a nanopore sequencing workflow for real-time analysis of brain tumors results in molecular classification within a 30-minute intraoperative window, followed by comprehensive profiling within 24 hours.

Areeba Patel
Kirsten Göbel
Felix Sahm
ResearchOpen Access25 Mar 2025
Nature Medicine

Volume: 31, P: 1567-1577
The long noncoding RNA H19 regulates tumor plasticity in neuroendocrine prostate cancer

Elevated expression of long noncoding RNA H19 is seen in clinical samples of neuroendocrine prostate cancer (PCa). Here the authors show H19 promotes plasticity from luminal to neuroendocrine by epigenetic reprogramming.

Neha Singh
Varune R. Ramnarine
Andrew S. Kraft
ResearchOpen Access21 Dec 2021
Nature Communications

Volume: 12, P: 1-20
Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine

Untargeted metabolomics demonstrate that apoptotic brown adipocytes release a specific pattern of metabolites with purine metabolites being highly enriched, and inosine is identified as a metabolite released during apoptosis regulating thermogenic fat and counteracting obesity.

Birte Niemann
Saskia Haufs-Brusberg
Alexander Pfeifer
ResearchOpen Access05 Jul 2022
Nature

Volume: 609, P: 361-368
EPAC1 enhances brown fat growth and beige adipogenesis

Reverte-Salisa et al. show that, in preadipocytes, EPAC1 enhances brown adipose tissue growth and increases the function of thermogenic fat in obesogenic conditions. Activation of EPAC1 induces human brown adipocyte proliferation and differentiation.

Laia Reverte-Salisa
Sana Siddig
Alexander Pfeifer
ResearchOpen Access09 Jan 2024
Nature Cell Biology

Volume: 26, P: 113-123
Engineering site-selective incorporation of fluorine into polyketides

A combination of engineering a fluorine-selective trans-acyltransferase and manipulation of the fluorinated extender unit pool in Escherichia coli enables the production of site-selectively fluorinated erythromycin precursors in vitro in vitroin vitro and in vivo.

Sasilada Sirirungruang
Omer Ad
Michelle C. Y. Chang
Research11 Jul 2022
Nature Chemical Biology

Volume: 18, P: 886-893
Variants in LRRC7 lead to intellectual disability, autism, aggression and abnormal eating behaviors

Here the authors identify 33 individuals with a dominant neurodevelopmental disorder due to heterozygous missense or loss-of-function variants in the gene encoding Densin-180, a scaffold protein present at postsynaptic sites in neurons of the central nervous system.

Jana Willim
Daniel Woike
Hans-Jürgen Kreienkamp
ResearchOpen Access10 Sept 2024
Nature Communications

Volume: 15, P: 1-18
Extracellular amyloid formation and associated pathology in neural grafts

Melanie Meyer-Luehmann
Martina Stalder
Mathias Jucker
Research24 Feb 2003
Nature Neuroscience

Volume: 6, P: 370-377
Aβ is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis

Martin C Herzig
David T Winkler
Mathias Jucker
Research15 Aug 2004
Nature Neuroscience

Volume: 7, P: 954-960
Microbial ecology of an Antarctic hypersaline lake: genomic assessment of ecophysiology among dominant haloarchaea

Timothy J Williams
Michelle A Allen
Ricardo Cavicchioli
Research20 Feb 2014
The ISME Journal

Volume: 8, P: 1645-1658
RASSF10 is frequently epigenetically inactivated in kidney cancer and its knockout promotes neoplasia in cancer prone mice

Antje M. Richter
Michelle L. Woods
Reinhard H. Dammann
ResearchOpen Access11 Feb 2020
Oncogene

Volume: 39, P: 3114-3127
Human induced pluripotent stem cell derived hepatocytes provide insights on parenteral nutrition associated cholestasis in the immature liver

T. Hang Nghiem-Rao
Courtney Pfeifer
Sridhar Rao
ResearchOpen Access11 Jun 2021
Scientific Reports

Volume: 11, P: 1-12
Histopathologic, immunophenotypic, and proteomics characteristics of low-grade phyllodes tumor and fibroadenoma: more similarities than differences

Lingxin Zhang
Chen Yang
Horacio M. Maluf
ResearchOpen Access26 Jun 2020
npj Breast Cancer

Volume: 6, P: 1-9
TET1 is a DNA-binding protein that modulates DNA methylation and gene transcription via hydroxylation of 5-methylcytosine

Haikuo Zhang
Xin Zhang
Yujiang Geno Shi
Correspondence16 Nov 2010
Cell Research

Volume: 20, P: 1390-1393