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Showing 1–8 of 8 results
Advanced filters: Author: Mickael Lelek Clear advanced filters

  • Retroviruses such as HIV integrate into the host genome as an essential step prior to their replication. Here Lelek et al. identify nuclear pore complex proteins that are essential for HIV nuclear import and productive integration, and show that the intranuclear protein Tpr influences integration into transcriptionally active chromatin.

    • Mickaël Lelek
    • Nicoletta Casartelli
    • Francesca Di Nunzio
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-12

  • Singh et al. report a constricted mitochondrial morphology called Ringo that forms during respiration growth in yeast. Inhibition of Ringo formation correlates with decreased respiration, potentially linking form to function.

    • Manish K. Singh
    • Laetitia Cavellini
    • Mickael M. Cohen
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • Respiratory syncytial virus (RSV) induces formation of inclusion bodies (IBs) sheltering viral RNA synthesis. Here, Rincheval et al. identify highly dynamic IB-associated granules (IBAGs) that accumulate newly synthetized viral mRNA and the viral M2-1 protein but exclude viral genomic RNA and RNA polymerase complexes.

    • Vincent Rincheval
    • Mickael Lelek
    • Marie-Anne Rameix-Welti
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11

  • This Primer explains the central concepts of single-molecule localization microscopy (SMLM) before discussing experimental considerations regarding fluorophores, optics and data acquisition, processing and analysis. The Primer further describes recent high-impact discoveries made by SMLM techniques and concludes by discussing emerging methodologies.

    • Mickaël Lelek
    • Melina T. Gyparaki
    • Christophe Zimmer
    Reviews
    Nature Reviews Methods Primers
    Volume: 1, P: 1-27