Nature Search

Deliberate removal of T cell help improves virus-neutralizing antibody production

Mike Recher
Karl S Lang
Rolf M Zinkernagel
Research08 Aug 2004
Nature Immunology

Volume: 5, P: 934-942
Hypergammaglobulinemia and autoantibody induction mechanisms in viral infections

Lukas Hunziker
Mike Recher
Rolf M. Zinkernagel
Research10 Mar 2003
Nature Immunology

Volume: 4, P: 343-349
SDHA gain-of-function engages inflammatory mitochondrial retrograde signaling via KEAP1–Nrf2

Hess and colleagues perform metabolic screens in B cells from patients with primary antibody deficiency and find that germline mutations in the succinate dehydrogenase subunit SDHA drive the expression of the cytokine IL-6 in patients with persistent polyclonal B cell lymphocytosis.

Anne-Valérie Burgener
Glenn R. Bantug
Christoph Hess
Research16 Sept 2019
Nature Immunology

Volume: 20, P: 1311-1321
Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus

Type 1 interferon limits virus replication. Lang and colleagues show that expression of Usp18 in metallophilic macrophages results in less interferon responsiveness, which allows locally restricted virus replication and the induction of adaptive immune responses.

Nadine Honke
Namir Shaabani
Karl S Lang
Research20 Nov 2011
Nature Immunology

Volume: 13, P: 51-57
Extralymphatic virus sanctuaries as a consequence of potent T-cell activation

Mike Recher
Karl S Lang
Rolf M Zinkernagel
Research04 Nov 2007
Nature Medicine

Volume: 13, P: 1316-1323
Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease

Karl S Lang
Mike Recher
Rolf M Zinkernagel
Research16 Jan 2005
Nature Medicine

Volume: 11, P: 138-145
Aggravation of viral hepatitis by platelet-derived serotonin

Philipp A Lang
Claudio Contaldo
Karl S Lang
Research30 May 2008
Nature Medicine

Volume: 14, P: 756-761
CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production

Antibody responses are regulated by selective survival of B cells with proper antigen specificity. Here the authors show that CEACAM1 is critical for B-cell survival during homeostasis and antiviral responses.

Vishal Khairnar
Vikas Duhan
Karl S. Lang
ResearchOpen Access18 Feb 2015
Nature Communications

Volume: 6, P: 1-13
Myeloperoxidase targets oxidative host attacks to Salmonella and prevents collateral tissue damage

Myeloperoxidase conversion of H₂O₂ to less-diffusible HOCl limits bystander host damage without comprising antibacterial activity during Salmonella infection.

Nura Schürmann
Pascal Forrer
Dirk Bumann
Research23 Jan 2017
Nature Microbiology

Volume: 2, P: 1-9
Author Correction: DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation

Haifa H. Jabara
Douglas R. McDonald
Raif S. Geha
Amendments and Corrections24 Mar 2022
Nature Immunology

Volume: 23, P: 815
DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation

Dock8 deficiency leads to defects in humoral immunity. Geha and colleagues show that Dock88 interacts with MyD88 to bridge TLR9 signaling to the Src-Syk-STAT3 pathway to promote B cell proliferation and differentiation.

Haifa H Jabara
Douglas R McDonald
Raif S Geha
Research13 May 2012
Nature Immunology

Volume: 13, P: 612-620
Reply to 'On the implications of polyclonal B cell activation'

Lukas Hunziker
Mike Recher
Rolf M. Zinkernagel
Correspondence01 Oct 2003
Nature Immunology

Volume: 4, P: 932
Immune system correlates of extensive limb swelling in response to conjugated pneumococcal vaccination

Mike Recher
Julia R. Hirsiger
Christoph T. Berger
ResearchOpen Access18 May 2018
npj Vaccines

Volume: 3, P: 1-4
Virus-specific antibodies allow viral replication in the marginal zone, thereby promoting CD8⁺ T-cell priming and viral control

Vikas Duhan
Vishal Khairnar
Karl S. Lang
ResearchOpen Access25 Jan 2016
Scientific Reports

Volume: 6, P: 1-14
CD169⁺ macrophages regulate PD-L1 expression via type I interferon and thereby prevent severe immunopathology after LCMV infection

Namir Shaabani
Vikas Duhan
Karl S Lang
ResearchOpen Access03 Nov 2016
Cell Death & Disease

Volume: 7, P: e2446

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Deliberate removal of T cell help improves virus-neutralizing antibody production

Hypergammaglobulinemia and autoantibody induction mechanisms in viral infections

SDHA gain-of-function engages inflammatory mitochondrial retrograde signaling via KEAP1–Nrf2

Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus

Extralymphatic virus sanctuaries as a consequence of potent T-cell activation

Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease

Aggravation of viral hepatitis by platelet-derived serotonin

CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production

Myeloperoxidase targets oxidative host attacks to Salmonella and prevents collateral tissue damage

Author Correction: DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation

DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation

Reply to 'On the implications of polyclonal B cell activation'

Immune system correlates of extensive limb swelling in response to conjugated pneumococcal vaccination

Virus-specific antibodies allow viral replication in the marginal zone, thereby promoting CD8⁺ T-cell priming and viral control

CD169⁺ macrophages regulate PD-L1 expression via type I interferon and thereby prevent severe immunopathology after LCMV infection

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