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Showing 301–350 of 491 results

Advanced filters: Author: Mike Thomas Clear advanced filters

NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Gα

LIN-5 acts at the cortex with Ga to control spindle positioning but is also localized at spindle poles. The LIN-5 interacting protein ASPM-1 and calmodulin are required for its recruitment to spindle poles and the LIN-5/ASPM-1/calmodulin complex regulates meiotic spindle positioning.

Monique van der Voet
Christian W. H. Berends
Sander van den Heuvel
Research15 Feb 2009
Nature Cell Biology

Volume: 11, P: 269-277
aPKC phosphorylates NuMA-related LIN-5 to position the mitotic spindle during asymmetric division

The LIN-5/NuMA pathway is needed to correctly position the mitotic spindle for asymmetric division. Now van den Heuvel and colleagues find that polarity kinase aPKC–PKC-3 phosphorylates LIN-5 to direct the localization of the spindle in the early embryos of Caenorhabditis elegans.

Matilde Galli
Javier Muñoz
Sander van den Heuvel
Research21 Aug 2011
Nature Cell Biology

Volume: 13, P: 1132-1138
Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes

Comprehensive integration of mutational and structural alterations in clinically-annotated DLBCL patient samples provides a novel molecular classification of the disease.

Bjoern Chapuy
Chip Stewart
Margaret A. Shipp
Research30 Apr 2018
Nature Medicine

Volume: 24, P: 679-690
Genetic and clinical variables act synergistically to impact neurodevelopmental outcomes in children with single ventricle heart disease

Miller, Hernandez et al. demonstrate a modest genetic contribution to neurodevelopmental and growth outcomes in single ventricle heart disease, and a markedly synergistic effect of genetic, demographic, and clinical variables. This shows the importance of quantifying the impact of genomic variants in the context of conditionally dependent variables.

Thomas A. Miller
Edgar J. Hernandez
Martin Tristani-Firouzi
ResearchOpen Access27 Sept 2023
Communications Medicine

Volume: 3, P: 1-9
The Mammalian Glucose Transporters

Sherin U Devaskar
Mike M Mueckler
Research01 Jan 1992
Pediatric Research

Volume: 31, P: 1-13
Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Evangelos Evangelou
Helen R. Warren
Mark J. Caulfield
Amendments and Corrections14 Nov 2018
Nature Genetics

Volume: 50, P: 1755
A qualitative study of GP, nurse and practice manager views on using targeted case-finding to identify patients with COPD in primary care

Rachael H. Summers
Taniya Sharmeen
Tom Wilkinson
ResearchOpen Access29 Aug 2017
npj Primary Care Respiratory Medicine

Volume: 27, P: 1-7
Author Correction: Elucidating causative gene variants in hereditary Parkinson’s disease in the Global Parkinson’s Genetics Program (GP2)

Lara M. Lange
Micol Avenali
Masharip Atadzhanov
Amendments and CorrectionsOpen Access13 Sept 2023
npj Parkinson's Disease

Volume: 9, P: 1-3
The importance of antimicrobial resistance in medical mycology

The impact of fungal infections on human health has been exacerbated by the rise of antifungal drug resistance. In this Review, the authors outline the problem of antifungal resistance and suggest how this growing threat might be mitigated.

Neil A. R. Gow
Carolyn Johnson
Keegan Edgar
ReviewsOpen Access12 Sept 2022
Nature Communications

Volume: 13, P: 1-12
Mendelian randomisation study of smoking exposure in relation to breast cancer risk

Hanla A. Park
Sonja Neumeyer
Jenny Chang-Claude
ResearchOpen Access02 Aug 2021
British Journal of Cancer

Volume: 125, P: 1135-1145
Case-finding for COPD clinic acceptability to patients in GPs across Hampshire: a qualitative study

Danielle Rose
Emma Ray
Tom M. A. Wilkinson
ResearchOpen Access04 Feb 2021
npj Primary Care Respiratory Medicine

Volume: 31, P: 1-8
A protease cascade regulates release of the human malaria parasite Plasmodium falciparum from host red blood cells

To exit from infected red blood cells, malaria parasites rely on the sequential action of different proteases, such as SUB1 and SERA6, in a process that culminates with the disassembly of the host cell’s cytoskeleton and rupture of the cell membrane.

James A. Thomas
Michele S. Y. Tan
Michael J. Blackman
Research19 Feb 2018
Nature Microbiology

Volume: 3, P: 447-455
Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

Lisa de las Fuentes
Yun Ju Sung
Myriam Fornage
Research05 May 2020
Molecular Psychiatry

Volume: 26, P: 2111-2125
Diverse species-specific phenotypic consequences of loss of function sorting nexin 14 mutations

Dale Bryant
Marian Seda
Philip Stanier
ResearchOpen Access13 Aug 2020
Scientific Reports

Volume: 10, P: 1-11
Radiomics Features Differentiate Between Normal and Tumoral High-Fdg Uptake

Chih-Yang Hsu
Mike Doubrovin
John T. Lucas Jr.
ResearchOpen Access02 Mar 2018
Scientific Reports

Volume: 8, P: 1-10
Epidemiology of 7375 children and adolescents hospitalized with COVID-19 in Germany, reported via a prospective, nationwide surveillance study in 2020–2022

Maren Doenhardt
Markus Hufnagel
Ulrich Zügge
ResearchOpen Access02 Jan 2024
Scientific Reports

Volume: 14, P: 1-15
Determinants of patient satisfaction in clozapine users: results from the Clozapine International Consortium (CLOZIN)

Marte Z. van der Horst
Nini de Boer
Jurjen J. Luykx
ResearchOpen Access23 Feb 2025
Schizophrenia

Volume: 11, P: 1-8
TILTomorrow today: dynamic factors predicting changes in intracranial pressure treatment intensity after traumatic brain injury

Shubhayu Bhattacharyay
Florian D. van Leeuwen
Tommaso Zoerle
ResearchOpen Access02 Jan 2025
Scientific Reports

Volume: 15, P: 1-18
Common variants at 6q22 and 17q21 are associated with intracranial volume

M. Arfan Ikram and colleagues report a genome-wide association study for intracranial volume and brain volume. They report two loci associated with intracranial volume.

M Arfan Ikram
Myriam Fornage
James F Wilson
Research15 Apr 2012
Nature Genetics

Volume: 44, P: 539-544
Convolutional neural network-based classification of glaucoma using optic radiation tissue properties

Kruper et al. investigate the impact of glaucoma on brain tissue by comparing MRI data from 856 people with glaucoma to matched controls without glaucoma. They find that neural networks using tissue properties from visual brain connections more accurately detect glaucoma than those trained on non-visual brain connections.

John Kruper
Adam Richie-Halford
Yalin Zheng
ResearchOpen Access11 Apr 2024
Communications Medicine

Volume: 4, P: 1-10
Looking beyond the exome: a phenotype-first approach to molecular diagnostic resolution in rare and undiagnosed diseases

Loren D M Pena
Yong-Hui Jiang
Vandana Shashi
Research14 Sept 2017
Genetics in Medicine

Volume: 20, P: 464-469
A combined binary interaction and phenotypic map of C. elegans cell polarity proteins

Boxem and colleagues perform a yeast two-hybrid screen to identify interactions between C. elegans polarity genes, followed by an RNAi screen to identify the functions of interaction pairs in the establishment and maintenance of cell polarity in various tissues.

Thijs Koorman
Diana Klompstra
Mike Boxem
Research18 Jan 2016
Nature Cell Biology

Volume: 18, P: 337-346
The potential role of optical biopsy in the study and diagnosis of environmental enteric dysfunction

Environmental enteric dysfunction (EED) is an important cause of impaired development and stunting in children in the developing world. In this Consensus Statement, the authors assess the potential of optical biopsy technologies to facilitate the study and diagnosis of this global burden.

Alex J. Thompson
Michael Hughes
Guang-Zhong Yang
ReviewsOpen Access15 Nov 2017
Nature Reviews Gastroenterology & Hepatology

Volume: 14, P: 727-738
A randomised open-label cross-over study of inhaler errors, preference and time to achieve correct inhaler use in patients with COPD or asthma: comparison of ELLIPTA with other inhaler devices

Job van der Palen
Mike Thomas
Neil C Barnes
ResearchOpen Access24 Nov 2016
npj Primary Care Respiratory Medicine

Volume: 26, P: 1-8
Decoding information about cognitive health from the brainwaves of sleep

Noor Adra
Lisa W. Dümmer
M. Brandon Westover
ResearchOpen Access15 Jul 2023
Scientific Reports

Volume: 13, P: 1-14
Solving patients with rare diseases through programmatic reanalysis of genome-phenome data

Leslie Matalonga
Carles Hernández-Ferrer
Andreas Rump
ResearchOpen Access01 Jun 2021
European Journal of Human Genetics

Volume: 29, P: 1337-1347
CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers

Nichola Johnson
Sarah Maguire
Olivia Fletcher
ResearchOpen Access26 Jan 2021
British Journal of Cancer

Volume: 124, P: 842-854
A comparison of pediatric inflammatory multisystem syndrome temporarily-associated with SARS-CoV-2 and Kawasaki disease

Markus Hufnagel
Jakob Armann
Ulrich Zügge
ResearchOpen Access20 Jan 2023
Scientific Reports

Volume: 13, P: 1-14
Mobilise-D insights to estimate real-world walking speed in multiple conditions with a wearable device

Cameron Kirk
Arne Küderle
Linda Van Gelder
ResearchOpen Access19 Jan 2024
Scientific Reports

Volume: 14, P: 1-23
Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup

Ashley A. Huggins
C. Lexi Baird
Rajendra Morey
ResearchOpen Access10 Jan 2024
Molecular Psychiatry

Volume: 29, P: 611-623
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

Stephen Sawcer
Garrett Hellenthal
Alastair Compston
Research10 Aug 2011
Nature

Volume: 476, P: 214-219
Comprehensive reanalysis for CNVs in ES data from unsolved rare disease cases results in new diagnoses

German Demidov
Burcu Yaldiz
Steven Laurie
ResearchOpen Access26 Oct 2024
npj Genomic Medicine

Volume: 9, P: 1-24
Macrodontia and double teeth: a review and case series

Sajida Mamdani
Divya Pathak
Nabina Bhujel
Research10 Mar 2023
British Dental Journal

Volume: 234, P: 315-321
ABS31: AKL1, a herbal treatment for asthma: a randomised controlled cross-over trial

Mike Thomas
Jane Sheran
Amanda Lee
Research Highlights01 Jun 2006
Primary Care Respiratory Journal

Volume: 15, P: 194
ABS82: Symptom pattern and antibiotic prescription in patients with acute cough

Mike Thomas
Rhiannon John
Cliodna McNulty
Research Highlights01 Jun 2006
Primary Care Respiratory Journal

Volume: 15, P: 208
Driving asthma care in Europe: the Brussels Declaration

John Haughney
Susanna Palkonen
Stephen Holgate
Editorial26 Mar 2009
Primary Care Respiratory Journal

Volume: 18, P: 55-56
ABS41: Montelukast as first-line preventative treatment for asthma in children age 2-5 yrs: A retrospective study

David Price
Julie von Ziegenweidt
Mike Thomas
Research Highlights01 Jun 2006
Primary Care Respiratory Journal

Volume: 15, P: 196
COPD management in the community: early detection and proactive care

Mike Thomas
Mark L. Levy
Editorial01 Feb 2005
Primary Care Respiratory Journal

Volume: 14, P: 5-7
ABS30: Validation of the ACQ (Juniper) in children: A pilot study

Kevin Gruffydd-Jones
Mike Thomas
Research Highlights01 Jun 2006
Primary Care Respiratory Journal

Volume: 15, P: 193
ABS006: Montelukast add-on therapy compared to high-dose inhaled corticosteroids in children age 2-5 yrs with asthma: a retrospective study

Mike Thomas
Julie von Ziegenweidt
David Price
Research Highlights01 Jun 2006
Primary Care Respiratory Journal

Volume: 15, P: 186
Utilizing a Simple Method for Stoichiometric Protein Labeling to Quantify Antibody Blockade

Rachel Friedman Ohana
Robin Hurst
Keith V. Wood
ResearchOpen Access07 May 2019
Scientific Reports

Volume: 9, P: 1-12
Asthma related quality of life and health economics

Mike Thomas
Research Highlights01 Jun 2002
Primary Care Respiratory Journal

Volume: 11, P: 72
Androgenesis from Festuca pratensis × Lolium multiflorum amphidiploid cultivars in order to select and stabilize rare gene combinations for grass breeding

A Leśniewska
A Ponitka
M W Humphreys
Research01 Feb 2001
Heredity

Volume: 86, P: 167-176
Multiple Myeloma DREAM Challenge reveals epigenetic regulator PHF19 as marker of aggressive disease

Mike J. Mason
Carolina Schinke
Justin Guinney
ResearchOpen Access14 Feb 2020
Leukemia

Volume: 34, P: 1866-1874
Correction to: Solve-RD: systematic pan-European data sharing and collaborative analysis to solve rare diseases

Birte Zurek
Kornelia Ellwanger
Andreas Rump
Amendments and Corrections13 Aug 2021
European Journal of Human Genetics

Volume: 29, P: 1459-1461
1,3-Diphenylureido hydroxamate as a promising scaffold for generation of potent antimalarial histone deacetylase inhibitors

Maurício T. Tavares
Arne Krüger
Roberto Parise-Filho
ResearchOpen Access29 Nov 2023
Scientific Reports

Volume: 13, P: 1-20
Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods

Jin Yang
Ashley A. Huggins
Aristeidis Sotiras
Research28 Nov 2023
Neuropsychopharmacology

Volume: 49, P: 609-619
Characterisation of PDGF-BB:PDGFRβ signalling pathways in human brain pericytes: evidence of disruption in Alzheimer’s disease

Smyth et al. use tissue microarrays from Alzheimer’s disease (AD) patient brains to show that PDGF-BB:PDGFRβ signalling components are reduced in AD. They then use primary human brain pericytes to elucidate a pathway by which PDGF-BB:PDGFRβ signalling in brain pericytes is disrupted in AD, thus impairing the blood brain barrier.

Leon C. D. Smyth
Blake Highet
Mike Dragunow
ResearchOpen Access17 Mar 2022
Communications Biology

Volume: 5, P: 1-16
mQC: A Heuristic Quality-Control Metric for High-Throughput Drug Combination Screening

Lu Chen
Kelli Wilson
Rajarshi Guha
ResearchOpen Access24 Nov 2016
Scientific Reports

Volume: 6, P: 1-14
Sequence-based Association Analysis Reveals an MGST1 eQTL with Pleiotropic Effects on Bovine Milk Composition

Mathew D. Littlejohn
Kathryn Tiplady
Richard J. Spelman
ResearchOpen Access05 May 2016
Scientific Reports

Volume: 6, P: 1-14

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