Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–8 of 8 results
Advanced filters: Author: Mikhail Kashlev Clear advanced filters

  • Transcription–replication conflicts can threaten genome stability. Here, the authors show that RNA polymerase II (Pol II) is a stronger roadblock to a DNA fork in the head-on orientation, and an RNA–DNA hybrid can form in front of Pol II, creating a topological lock trapping Pol II at the fork.

    • Taryn M. Kay
    • James T. Inman
    • Michelle D. Wang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • Transcription by bacterial RNA polymerase is interrupted by pausing events that play diverse regulatory roles. Here, the authors find that a large number of E. coli sigma70-dependent pauses, clustered at a 10−20-bp distance from promoters, are regulated by Gre cleavage factors constituting a mechanism for rapid response to changing environmental cues.

    • Zhe Sun
    • Alexander V. Yakhnin
    • Mikhail Kashlev
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • What happens to histones during transcription is not well understood. Atomic force microscopy snapshots of RNA polymerase II (Pol II)-nucleosome complexes before, during and after transcription show the presence of looped transcriptional intermediates. In addition, a fraction of transcribed histones are remodeled to hexasomes, and the size of this fraction depends on the elongation rate of Pol II.

    • Lacramioara Bintu
    • Marta Kopaczynska
    • Carlos Bustamante
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 1394-1399

  • Genomic instability can result from stalled or collapsed replication fork at sites of unrepaired DNA lesions. Here the authors uncover a new lesion bypass pathway for the T7 replisome, where leading strand template lesions can be overcome through interaction between the replisome's helicase and polymerase components.

    • Bo Sun
    • Manjula Pandey
    • Michelle D. Wang
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-8

  • Previous studies have indicated that the nucleosome poses a barrier to the passage of RNA polymerase. It is now shown that a trailing bacterial RNA polymerase can reduce backtracking and enhance the movement of a leading polymerase through the nucleosomal barrier.

    • Jing Jin
    • Lu Bai
    • Michelle D Wang
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 745-752