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Advanced filters: Author: Miki Hayano Clear advanced filters
  • Modulatory profiling of lethal small-molecule compounds identified FIN56 as an inducer of ferroptosis. FIN56 promotes the degradation of glutathione peroxidase 4 and directly activates squalene synthase, an enzyme involved in cholesterol synthesis.

    • Kenichi Shimada
    • Rachid Skouta
    • Brent R Stockwell
    Research
    Nature Chemical Biology
    Volume: 12, P: 497-503