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Showing 1–7 of 7 results

Advanced filters: Author: Mikiko Kaneko Clear advanced filters

Combined inhibition of XIAP and BCL2 drives maximal therapeutic efficacy in genetically diverse aggressive acute myeloid leukemia

Ishikawa and colleagues perform integrated genomic and drug-sensitivity screens with extensive PDX modeling and reveal combined XIAP and BCL2 inhibition as a vulnerability hub across AML genetic alterations.

Mari Hashimoto
Yoriko Saito
Fumihiko Ishikawa
Research18 Mar 2021
Nature Cancer

Volume: 2, P: 340-356
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Time-course changes in fingernail cortisol levels during pregnancy and postpartum

Shuhei Izawa
Mikiko Kawasaki
Shusaku Nomura
ResearchOpen Access11 Jan 2024
Scientific Reports

Volume: 14, P: 1-7
Nardilysin regulates axonal maturation and myelination in the central and peripheral nervous system

Nardilysin (NRDc) enhances the shedding of ectodomains from neuronal membrane proteins. The null mutant described here reveals that nardilysin is necessary for myelination in both central and peripheral nervous system.

Mikiko Ohno
Yoshinori Hiraoka
Eiichiro Nishi
Research22 Nov 2009
Nature Neuroscience

Volume: 12, P: 1506-1513
Determination of starting dose of the T cell-redirecting bispecific antibody ERY974 targeting glypican-3 in first-in-human clinical trial

Shun-ichiro Komatsu
Yoko Kayukawa
Yuji Sano
ResearchOpen Access19 Jul 2022
Scientific Reports

Volume: 12, P: 1-11
Survey on experiences and attitudes of parents toward disclosing information to children with genetic syndromes and their siblings in Japan

Mikiko Kaneko
Daiju Oba
Hirofumi Ohashi
ResearchOpen Access08 Sept 2022
Scientific Reports

Volume: 12, P: 1-9
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14