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descSPIM: an affordable and easy-to-build light-sheet microscope optimized for tissue clearing techniques

Poor access to suitable light-sheet microscopes remains a big obstacle for many end-users in biomedical research. Here, the authors present descSPIM, a low-cost, low-expertise light-sheet microscope for routine 3D imaging of cleared samples.

Kohei Otomo
Takaki Omura
Etsuo A. Susaki
ResearchOpen Access12 Jun 2024
Nature Communications

Volume: 15, P: 1-19
Raft-based interactions of gangliosides with a GPI-anchored receptor

Monitoring new fluorescent ganglioside analogs at a single-molecule level suggests that gangliosides associate dynamically with GPI-anchored protein monomers, transient homodimer rafts, and clustered signaling rafts in a cholesterol-dependent manner.

Naoko Komura
Kenichi G N Suzuki
Makoto Kiso
Research04 Apr 2016
Nature Chemical Biology

Volume: 12, P: 402-410
The Neuroprotective Effect of Thalidomide against Ischemia through the Cereblon-mediated Repression of AMPK Activity

Naoya Sawamura
Mariko Yamada
Toru Asahi
ResearchOpen Access06 Feb 2018
Scientific Reports

Volume: 8, P: 1-9