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Showing 1–10 of 10 results
Advanced filters: Author: Mila Lamb Clear advanced filters

  • A method for de novo design of peptide macrocyles called RFpeptides has been developed. RFpeptides is an extension of RoseTTAFold2 and RFdiffusion and combines structure prediction and protein backbone generation for rapid and custom design of macrocyclic peptide binders.

    • Stephen A. Rettie
    • David Juergens
    • Gaurav Bhardwaj
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 21, P: 1948-1956

  • AfCycDesign: Cyclic offset to the relative positional encoding in AlphaFold2 enables accurate structure prediction, sequence redesign, and de novo hallucination of cyclic peptide monomers and binders.

    • Stephen A. Rettie
    • Katelyn V. Campbell
    • Gaurav Bhardwaj
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Jiang et al. developed a computational method to design repeat proteins with multiple structured loops that are buttressed by extensive hydrogen bond networks. The designs were further functionalized into high-affinity peptide-binding proteins.

    • Hanlun Jiang
    • Kevin M. Jude
    • David Baker
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 20, P: 974-980

  • Designed novel protein nanoparticle technology integrates antibody targeting and responds to changes in environmental conditions to release protected molecular cargoes, opening new applications for precision medicine.

    • Erin C. Yang
    • Robby Divine
    • David Baker
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 31, P: 1404-1412

  • An approach to design proteins that can capture amyloidogenic protein regions present in, for example, tau and Aβ42 has now been developed. These designer proteins can inhibit the formation of pathogenic amyloid fibrils and protect cells from toxic species.

    • Danny D. Sahtoe
    • Ewa A. Andrzejewska
    • David Baker
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 20, P: 981-990

  • Molecular systems with coincident cyclic and superhelical symmetry axes have considerable advantages for materials design as they can be lengthened or shortened by changing the length of the monomers. Now a systematic approach to generate modular repeat protein oligomers with combined symmetry that can be extended by repeat propagation has been developed.

    • Neville P. Bethel
    • Andrew J. Borst
    • David Baker
    ResearchOpen Access
    Nature Chemistry
    Volume: 15, P: 1664-1671