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Astrocytic lactate dehydrogenase A regulates neuronal excitability and depressive-like behaviors through lactate homeostasis in mice

The role of glycolysis in depression is unclear. Here the authors report a glycolytic deficit under social stress and demonstrate that astrocytic LDHA affects neuronal excitability and depressive-like behaviours via lactate homeostasis in mice.

Shan Yao
Min-Dong Xu
Xiang-Dong Sun
ResearchOpen Access09 Feb 2023
Nature Communications

Volume: 14, P: 1-18
Identification of TFPI as a receptor reveals recombination-driven receptor switching in Clostridioides difficile toxin B variants

Toxin B (TcdB) is a major exotoxin responsible for diseases associated with C. difficile infection. Here, Tian et al. show that several TcdB subtypes do not recognize the established FZD receptors, and identify a different host protein (TFPI) as a receptor for subtypes TcdB4 and TcdB10.

Songhai Tian
Xiaozhe Xiong
Min Dong
ResearchOpen Access09 Nov 2022
Nature Communications

Volume: 13, P: 1-19
Ancient Clostridium DNA and variants of tetanus neurotoxins associated with human archaeological remains

The analysis of microbial genomes from human archaeological samples offers a snapshot of ancient pathogens. Here, Hodgins et al. analyze metagenomic datasets from 38 human archaeological samples and identify bacterial genomic sequences related to modern-day Clostridium tetani, encoding tetanus neurotoxins.

Harold P. Hodgins
Pengsheng Chen
Andrew C. Doxey
ResearchOpen Access06 Sept 2023
Nature Communications

Volume: 14, P: 1-15
Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection

Chondroitin sulfate proteoglycan 4 (CSPG4) is a potential receptor for C. difficile toxin B (TcdB) during C. difficile infections (CDIs). Here, the cryo-EM structure of a TcdB–CSPG4 complex and CDI mouse models offer insights into CSPG4 role in CDIs and suggest a therapeutic strategy targeting TcdB.

Peng Chen
Ji Zeng
Rongsheng Jin
ResearchOpen Access18 Jun 2021
Nature Communications

Volume: 12, P: 1-13
Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2

Botulinum neurotoxin E (BoNT/E) is a major cause of botulism and paradoxically also a drug in clinical trial. Here, the authors show that BoNT/E binding and uptake require glycosylation of its host receptor SV2 with high selectivity for SV2A and SV2B over SV2C.

Zheng Liu
Pyung-Gang Lee
Rongsheng Jin
ResearchOpen Access24 Apr 2023
Nature Communications

Volume: 14, P: 1-14
Reference gene selection for qRT-PCR analyses of luffa (Luffa cylindrica) plants under abiotic stress conditions

Min-dong Chen
Bin Wang
Qing-fang Wen
ResearchOpen Access04 Feb 2021
Scientific Reports

Volume: 11, P: 1-12

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Astrocytic lactate dehydrogenase A regulates neuronal excitability and depressive-like behaviors through lactate homeostasis in mice

Identification of TFPI as a receptor reveals recombination-driven receptor switching in Clostridioides difficile toxin B variants

Ancient Clostridium DNA and variants of tetanus neurotoxins associated with human archaeological remains

Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection

Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2

Reference gene selection for qRT-PCR analyses of luffa (Luffa cylindrica) plants under abiotic stress conditions

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Astrocytic lactate dehydrogenase A regulates neuronal excitability and depressive-like behaviors through lactate homeostasis in mice

Identification of TFPI as a receptor reveals recombination-driven receptor switching in Clostridioides difficile toxin B variants

Ancient Clostridium DNA and variants of tetanus neurotoxins associated with human archaeological remains

Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection

Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2

Reference gene selection for qRT-PCR analyses of luffa (Luffa cylindrica) plants under abiotic stress conditions

Search

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