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IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes

Most of the more than 200 known genetic risk loci for inflammatory bowel disease (IBD) reside in regulatory regions. Here, the authors provide eQTL datasets for six circulating immune cell types and ileal, colonic and rectal biopsies to map regulatory modules and identify potential causative genes for IBD.

Yukihide Momozawa
Julia Dmitrieva
Michel Georges
ResearchOpen Access21 Jun 2018
Nature Communications

Volume: 9, P: 1-18
One-pot amphiphilic engineering of bioresorbable polymers for constructing colloidal vesicles and prolonging protein delivery

This study describes the production of the amphiphilic bioresorbable polymers sorbitan–PLA and PEG–PLA in a single reactor. This method aims to simplify the separation process and reduce purification costs while increasing the chemical yield. The obtained mixtures could stabilize squalene/water interfaces, resulting in a double-dispersion structure that is favorable for encapsulation in sustained delivery applications.

Chiung-Yi Huang
Yu-Jhen Cheng
Ming-Hsi Huang
Research24 Sept 2019
Polymer Journal

Volume: 52, P: 237-244
Degradable emulsion as vaccine adjuvant reshapes antigen-specific immunity and thereby ameliorates vaccine efficacy

Chung-Hsiung Huang
Chiung-Yi Huang
Ming-Hsi Huang
ResearchOpen Access09 Nov 2016
Scientific Reports

Volume: 6, P: 1-9
Synthesis and thermal investigation of phosphate-functionalized acrylic materials

Phosphate-functionalized acrylic materials were synthesized by free-radical polymerizations of MMA and DMP using the BPO-DMpT initiated reaction system. The resulting products were able to react with the HEMA monomer, thus yielding polymers with a chain structure of P(MMA-co-DMP)-b-PHEMA. Remarkably, incorporating DMP and/or PHEMA into PMMA main chain rendered a copolymer with low T_g while increasing the T_d intrinsic to PMMA. The enhancement of overall thermal stability of the acrylic materials is a feature of great interest for applications in bone cements and coating system additives.

Yun-Fen Peng
Ashley Tsai
Ming-Hsi Huang
Research06 Jun 2018
Polymer Journal

Volume: 50, P: 967-974
High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis

John Rioux, Andre Franke, Tom Karlsen and colleagues perform a fine-mapping study of the HLA region in Crohn's disease and ulcerative colitis. They identify a primary role for HLA-DRB1*01:03 in both diseases and find evidence of heterozygous advantage in protection against ulcerative colitis.

Philippe Goyette
Gabrielle Boucher
John D Rioux
Research05 Jan 2015
Nature Genetics

Volume: 47, P: 172-179

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IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes

One-pot amphiphilic engineering of bioresorbable polymers for constructing colloidal vesicles and prolonging protein delivery

Degradable emulsion as vaccine adjuvant reshapes antigen-specific immunity and thereby ameliorates vaccine efficacy

Synthesis and thermal investigation of phosphate-functionalized acrylic materials

High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis

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