Nature Search

Measurements of face mask’s capability to block ionizing radiation

Hsingtzu Wu
Hong-Da Liu
Ming-Wei Lin
ResearchOpen Access22 Feb 2025
Scientific Reports

Volume: 15, P: 1-7
Patterned arrays of lateral heterojunctions within monolayer two-dimensional semiconductors

Lateral heterojunctions between two-dimensional semiconductor crystals are essential building blocks for electronic devices. Here, the authors utilize electron-beam lithography and selective conversion to simultaneously fabricate arrays of molybdenum diselenide–molybdenum disulfide heterojunctions.

Masoud Mahjouri-Samani
Ming-Wei Lin
David B. Geohegan
ResearchOpen Access22 Jul 2015
Nature Communications

Volume: 6, P: 1-6
High-throughput screening of novel antagonists on melanin-concentrating hormone receptor-1

Jian-hua Yan
Qun-yi Li
Ming-wei Wang
Research01 Jun 2008
Acta Pharmacologica Sinica

Volume: 29, P: 752-758
W2476 ameliorates β-cell dysfunction and exerts therapeutic effects in mouse models of diabetes via modulation of the thioredoxin-interacting protein signaling pathway

Ting Li
Guang-yao Lin
Ming-wei Wang
Research15 May 2017
Acta Pharmacologica Sinica

Volume: 38, P: 1024-1037
Correction: Corrigendum: Daxx inhibits hypoxia-induced lung cancer cell metastasis by suppressing the HIF-1α/HDAC1/Slug axis

Ching-Wen Lin
Lu-Kai Wang
Pan-Chyr Yang
Amendments and CorrectionsOpen Access07 Feb 2017
Nature Communications

Volume: 8, P: 1
Daxx inhibits hypoxia-induced lung cancer cell metastasis by suppressing the HIF-1α/HDAC1/Slug axis

Hypoxia and epithelial-to-mesenchymal transition promotes cancer metastasis. Here the authors show that Daxx inhibits hypoxia-induced lung cancer metastasis by attenuating Slug-mediated transcriptional repression of epithelial-like markers that in turn cause cells to exhibit low invasiveness.

Ching-Wen Lin
Lu-Kai Wang
Pan-Chyr Yang
ResearchOpen Access22 Dec 2016
Nature Communications

Volume: 7, P: 1-16
Whole genomic analysis reveals atypical non-homologous off-target large structural variants induced by CRISPR-Cas9-mediated genome editing

The safety of CRISPR-Cas9 editing is a concern. Here the authors use whole genomic analysis by 10x linked-read sequencing and optical genome mapping to interrogate the genome integrity after editing: they see large structural variants at on-target sites and unexpected large chromosomal deletions.

Hsiu-Hui Tsai
Hsiao-Jung Kao
John Yu
ResearchOpen Access25 Aug 2023
Nature Communications

Volume: 14, P: 1-9
Fragile X syndrome carrier screening in pregnant women in Chinese Han population

Chia-Cheng Hung
Chien-Nan Lee
Shin-Yu Lin
ResearchOpen Access29 Oct 2019
Scientific Reports

Volume: 9, P: 1-7
GPCR activation and GRK2 assembly by a biased intracellular agonist

Structural studies on the complex containing G-protein-coupled receptor kinase 2 (GRK2), neurotensin receptor 1 (NTSR1), Gα_q and the arrestin-biased ligand SBI-553 provide insights into these interactions and a foundation for the design of arrestin-biased ligands for G-protein-coupled receptors.

Jia Duan
Heng Liu
H. Eric Xu
Research02 Aug 2023
Nature

Volume: 620, P: 676-681
Structures of G_i-bound metabotropic glutamate receptors mGlu2 and mGlu4

Cryo-electron microscopy structures of mGlu2 and mGlu4 bound to heterotrimeric G_i protein shed light on the molecular basis of asymmetric signal transduction by metabotropic glutamate receptors.

Shuling Lin
Shuo Han
Beili Wu
Research16 Jun 2021
Nature

Volume: 594, P: 583-588
Ganoderma tsuage promotes pain sensitivity in aging mice

Kai-Ning Yang
Chia-Ying Lin
Chia-Yi Tseng
ResearchOpen Access21 May 2024
Scientific Reports

Volume: 14, P: 1-8
High-throughput screening campaign identifies a small molecule agonist of the relaxin family peptide receptor 4

Guang-yao Lin
Lin Lin
Ming-wei Wang
Research31 Mar 2020
Acta Pharmacologica Sinica

Volume: 41, P: 1328-1336
Full-length human GLP-1 receptor structure without orthosteric ligands

Glucagon-like peptide-1 receptor (GLP-1R) plays an important role in glucose homeostasis and treatment of type 2 diabetes. Here authors report the peptide-free crystal structure of human GLP-1R in an inactive state which reveals a unique closed conformation of the extracellular domain.

Fan Wu
Linlin Yang
Raymond C. Stevens
ResearchOpen Access09 Mar 2020
Nature Communications

Volume: 11, P: 1-10
Erlotinib versus gemcitabine plus cisplatin as neoadjuvant treatment of stage IIIA-N2 EGFR-mutant non-small-cell lung cancer: final overall survival analysis of the EMERGING-CTONG 1103 randomised phase II trial

Wen-Zhao Zhong
Hong-Hong Yan
Yi-Long Wu
ResearchOpen Access24 Feb 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-8
Plasma phenylalanine and glutamine concentrations correlate with subsequent hepatocellular carcinoma occurrence in liver cirrhosis patients: an exploratory study

Kung-Hao Liang
Mei-Ling Cheng
Chau-Ting Yeh
ResearchOpen Access02 Jul 2020
Scientific Reports

Volume: 10, P: 1-7
Structure of the full-length glucagon class B G-protein-coupled receptor

The crystal structure of the full-length human glucagon receptor reveals the essential role of the 12-residue ‘stalk’ segment and an extracellular loop in the regulation of ligand binding and receptor activation.

Haonan Zhang
Anna Qiao
Beili Wu
Research17 May 2017
Nature

Volume: 546, P: 259-264
UGT2B28 genomic variation is associated with hepatitis B e-antigen seroconversion in response to antiviral therapy

Kung-Hao Liang
Chih-Lang Lin
Chau-Ting Yeh
ResearchOpen Access26 Sept 2016
Scientific Reports

Volume: 6, P: 1-8
The Effect of Ganoderma Microsporum immunomodulatory proteins on alleviating PM_2.5-induced inflammatory responses in pregnant rats and fine particulate matter-induced neurological damage in the offsprings

Chia-Yi Tseng
Jia-Yu Yu
Ming-Wei Chao
ResearchOpen Access02 May 2019
Scientific Reports

Volume: 9, P: 1-10
Intestinal microbiome in children with severe and complicated acute viral gastroenteritis

Shih-Yen Chen
Chi-Neu Tsai
Cheng-Hsun Chiu
ResearchOpen Access11 Apr 2017
Scientific Reports

Volume: 7, P: 1-7
Oral FPR2/ALX modulators tune myeloid cell activity to ameliorate mucosal inflammation in inflammatory bowel disease

Wen-sheng Yang
Qing Liu
Zhi-ping Li
Research11 Mar 2025
Acta Pharmacologica Sinica

Volume: 46, P: 1958-1973
Analysis and identification of oxidative stress-ferroptosis related biomarkers in ischemic stroke

Lin-Ming Zhang
Xing-ling Liang
Ming-wei Liu
ResearchOpen Access15 Feb 2024
Scientific Reports

Volume: 14, P: 1-15
Derivatives of aryl-4-guanidinomethylbenzoate and N-aryl-4-guanidinomethylbenzamide as new antibacterial agents: synthesis and bioactivity

Wen-yuan Yu
Li-xia Yang
Ming-wei Wang
Research01 Feb 2008
Acta Pharmacologica Sinica

Volume: 29, P: 267-277
miR-548aq-3p is a novel target of Far infrared radiation which predicts coronary artery disease endothelial colony forming cell responsiveness

Wei-Che Tsai
Wei-Hui Chiang
Cheng-Chung Cheng
ResearchOpen Access22 Apr 2020
Scientific Reports

Volume: 10, P: 1-17
Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators

Crystal structures of the human GLP-1 receptor in complex with two negative allosteric modulators reveal a common binding pocket, and, together with mutagenesis and modelling studies, further our understanding of the receptor activation mechanism.Author: Please check the wording of the following statement, which will appear online only.

Gaojie Song
Dehua Yang
Raymond C. Stevens
Research17 May 2017
Nature

Volume: 546, P: 312-315
Author Correction: Ganoderma tsuage promotes pain sensitivity in aging mice

Kai-Ning Yang
Chia-Ying Lin
Chia‑Yi Tseng
Amendments and CorrectionsOpen Access10 Sept 2024
Scientific Reports

Volume: 14, P: 1
Genetic variation of SORBS1 gene is associated with glucose homeostasis and age at onset of diabetes: A SAPPHIRe Cohort Study

Tien-Jyun Chang
Wen-Chang Wang
I-Te Lee
ResearchOpen Access12 Jul 2018
Scientific Reports

Volume: 8, P: 1-10
Novel IL31RA gene mutation and ancestral OSMR mutant allele in familial primary cutaneous amyloidosis

Ming-Wei Lin
Ding-Dar Lee
Shih-Feng Tsai
Research19 Aug 2009
European Journal of Human Genetics

Volume: 18, P: 26-32
Prevalence and associated factors of metabolic syndrome among people living with HIV in a medical center of Northern Taiwan

Chien-An Tu
Chien-Feng Kuo
Alice Ying-Jung Wu
ResearchOpen Access07 Feb 2025
Scientific Reports

Volume: 15, P: 1-8
Formyl peptide receptor 2 as a potential therapeutic target for inflammatory bowel disease

Wen-sheng Yang
Jing-lin Wang
Zhi-ping Li
Reviews15 Jul 2022
Acta Pharmacologica Sinica

Volume: 44, P: 19-31
GALNT14-mediated O-glycosylation on PHB2 serine-161 enhances cell growth, migration and drug resistance by activating IGF1R cascade in hepatoma cells

Yu-De Chu
Tan-Chi Fan
Chau-Ting Yeh
ResearchOpen Access14 Nov 2022
Cell Death & Disease

Volume: 13, P: 1-13
A GALNT14 rs9679162 genotype-guided therapeutic strategy for advanced hepatocellular carcinoma: systemic or hepatic arterial infusion chemotherapy

Chen-Chun Lin
Chao-Wei Hsu
Chau-Ting Yeh
Research14 Oct 2019
The Pharmacogenomics Journal

Volume: 20, P: 57-68
Aldolase B-driven lactagenesis and CEACAM6 activation promote cell renewal and chemoresistance in colorectal cancer through the Warburg effect

Yu-De Chu
Li-Chun Cheng
Wey-Ran Lin
ResearchOpen Access10 Oct 2023
Cell Death & Disease

Volume: 14, P: 1-14
Targeting the up-regulated CNOT3 reverses therapeutic resistance and metastatic progression of EGFR-mutant non-small cell lung cancer

Lin Jing
Meng-En Zhai
Jian-Li Jiang
ResearchOpen Access02 Nov 2023
Cell Death Discovery

Volume: 9, P: 1-12
Single-Shot Measurement of Temporally-Dependent Polarization State of Femtosecond Pulses by Angle-Multiplexed Spectral-Spatial Interferometry

Ming-Wei Lin
Igor Jovanovic
ResearchOpen Access06 Sept 2016
Scientific Reports

Volume: 6, P: 1-10
Genetic profiles of 103,106 individuals in the Taiwan Biobank provide insights into the health and history of Han Chinese

Chun-Yu Wei
Jenn-Hwai Yang
Pui-Yan Kwok
ResearchOpen Access11 Feb 2021
npj Genomic Medicine

Volume: 6, P: 1-10
Safety and immunogenicity of a recombinant COVID-19 vaccine (Sf9 cells) in healthy population aged 18 years or older: two single-center, randomised, double-blind, placebo-controlled, phase 1 and phase 2 trials

Fan-Yue Meng
Fan Gao
Feng-Cai Zhu
ResearchOpen Access15 Jul 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-11
Pulsatile ocular blood flow in patients with Graves' ophthalmopathy

Chieh-Chih Tsai
Hui-Chuan Kau
Yau-Huei Wei
Research18 Jun 2004
Eye

Volume: 19, P: 159-162
High-throughput screening of antagonists for the orphan G-protein coupled receptor GPR139

Jia Wang
Lin-yun Zhu
Ming-wei Wang
Research01 Jun 2015
Acta Pharmacologica Sinica

Volume: 36, P: 874-878
Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G_s proteins

Zhaotong Cong
Fenghui Zhao
Ming-Wei Wang
ResearchOpen Access13 Feb 2024
Cell Discovery

Volume: 10, P: 1-13
Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors

Wenbo Feng
Qingtong Zhou
Ming-Wei Wang
ResearchOpen Access31 Jul 2023
Cell Discovery

Volume: 9, P: 1-15
Correction: Corrigendum: Intestinal microbiome in children with severe and complicated acute viral gastroenteritis

Shih-Yen Chen
Chi-Neu Tsai
Cheng-Hsun Chiu
Amendments and CorrectionsOpen Access26 May 2017
Scientific Reports

Volume: 7, P: 1
The BDNF Val66Met polymorphism is associated with the functional connectivity dynamics of pain modulatory systems in primary dysmenorrhea

Shyh-Yuh Wei
Hsiang-Tai Chao
Jen-Chuen Hsieh
ResearchOpen Access24 Mar 2016
Scientific Reports

Volume: 6, P: 1-11
Transmembrane and coiled-coil domain family 3 (TMCC3) regulates breast cancer stem cell and AKT activation

Ya-Hui Wang
Yu-Tzu Chan
Alice L. Yu
ResearchOpen Access19 Mar 2021
Oncogene

Volume: 40, P: 2858-2871
Comparison of proximal versus distal upper-limb robotic rehabilitation on motor performance after stroke: a cluster controlled trial

Yu-wei Hsieh
Keh-chung Lin
Chia-ling Chen
ResearchOpen Access01 Feb 2018
Scientific Reports

Volume: 8, P: 1-11
The OPRM1 A118G polymorphism modulates the descending pain modulatory system for individual pain experience in young women with primary dysmenorrhea

Shyh-Yuh Wei
Li-Fen Chen
Jen-Chuen Hsieh
ResearchOpen Access06 Jan 2017
Scientific Reports

Volume: 7, P: 1-11
The effects of artocarpin on wound healing: in vitro and in vivo studies

Chung-Ju Yeh
Chin-Chuan Chen
Shu-Huei Wang
ResearchOpen Access15 Nov 2017
Scientific Reports

Volume: 7, P: 1-13
Controlled Vapor Phase Growth of Single Crystalline, Two-Dimensional GaSe Crystals with High Photoresponse

Xufan Li
Ming-Wei Lin
Kai Xiao
ResearchOpen Access30 Jun 2014
Scientific Reports

Volume: 4, P: 1-9
Nanoforging Single Layer MoSe₂ Through Defect Engineering with Focused Helium Ion Beams

Vighter Iberi
Liangbo Liang
Olga S. Ovchinnikova
ResearchOpen Access02 Aug 2016
Scientific Reports

Volume: 6, P: 1-9
A homotrimeric GPCR architecture of the human cytomegalovirus revealed by cryo-EM

Yanyan Chen
Yang Li
Ming-Wei Wang
CorrespondenceOpen Access16 May 2024
Cell Discovery

Volume: 10, P: 1-4
China’s first step towards probing the expanding universe and the nature of gravity using a space borne gravitational wave antenna

Gravitational wave astronomy has opened the door to test general relativity and the effect of gravity in the Universe. The authors present the capabilities of an overlap between space gravitational wave detectors LISA and Taiji to constrain the Hubble constant to 0.5%, in 10 years, and what can be learned from the satellite pilot Taiji-1 launched in 2019.

Yue-Liang Wu
Zi-Ren Luo
Zi-Ming Zou
ReviewsOpen Access24 Feb 2021
Communications Physics

Volume: 4, P: 1-7

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