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Showing 1–3 of 3 results
Advanced filters: Author: Mingcan Yu Clear advanced filters

  • T cells are involved in the bone loss induced by parathyroid hormone (PTH), but their origin is unknown. Here, the authors show that the intestinal microbiota is required for PTH to induce bone loss and describes mechanisms for microbiota-mediated gut–bone crosstalk in mouse models of hyperparathyroidism.

    • Mingcan Yu
    • Abdul Malik Tyagi
    • Roberto Pacifici
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17

  • Human T cell function declines with age, reducing the ability of vaccines to protect the elderly against infectious disease. In this issue, Jörg Goronzy and his colleagues shed light on the mechanism by which naive CD4+ T cell responses are impaired in elderly individuals. The researchers show that miR-181a is reduced in these cells in older individuals. This results in increased expression of DUSP6, a phosphatase that dampens ERK signaling, which is necessary for optimal T cell receptor sensitivity to antigen.

    • Guangjin Li
    • Mingcan Yu
    • Jörg J Goronzy
    Research
    Nature Medicine
    Volume: 18, P: 1518-1524