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BIK1 protein homeostasis is maintained by the interplay of different ubiquitin ligases in immune signaling

The cytoplasmic kinase BIK1 plays a central role in immune signaling and its protein homeostasis is maintained by the interplay of the ubiquitin ligases RGLG1/2 and PUB25 - RGLG1/2 suppress PUB25-mediated BIK1 protein degradation.

Jiaojiao Bai
Yuanyuan Zhou
Dongping Lu
ResearchOpen Access02 Aug 2023
Nature Communications

Volume: 14, P: 1-14

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BIK1 protein homeostasis is maintained by the interplay of different ubiquitin ligases in immune signaling

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