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Author Correction: Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src

Zhenxi Li
Xinghai Yang
Jianru Xiao
Amendments and CorrectionsOpen Access19 Dec 2024
Nature Communications

Volume: 15, P: 1
Scaling up spatial transcriptomics for large-sized tissues: uncovering cellular-level tissue architecture beyond conventional platforms with iSCALE

iSCALE leverages histology and spatial transcriptomics to infer gene expression at super resolution in large tissues.

Amelia Schroeder
Melanie L. Loth
Mingyao Li
ResearchOpen Access15 Sept 2025
Nature Methods

Volume: 22, P: 1911-1922
Leveraging deep single-soma RNA sequencing to explore the neural basis of human somatosensation

Dorsal root ganglia (DRGs) contain a plethora of neuron types. The authors show that the existence of human-specific DRG neuronal types and microneurography recordings reveal distinct temperature-sensing properties across human sensory afferent types.

Huasheng Yu
Saad S. Nagi
Wenqin Luo
ResearchOpen Access04 Nov 2024
Nature Neuroscience

Volume: 27, P: 2326-2340
Spatial transcriptomics reveals human cortical layer and area specification

Multiplexed error-robust fluorescence in situ hybridization (MERFISH) together with deep-learning-based nucleus segmentation enabled the construction of a highly detailed and informative spatially resolved single-cell atlas of human fetal cortical development.

Xuyu Qian
Kyle Coleman
Christopher A. Walsh
ResearchOpen Access14 May 2025
Nature

Volume: 644, P: 153-163
Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src

The authors of this manuscript identify that Gpr54 activation by its natural ligand Kisspeptin-10 can abrogate bone resorption. Mechanistically, Gpr54 recruits both active Src and the Dusp18 phosphatase, which causes Dusp18 to dephosphorylate Src at Tyr 416.

Zhenxi Li
Xinghai Yang
Jianru Xiao
ResearchOpen Access12 Feb 2024
Nature Communications

Volume: 15, P: 1-17
GnIH secreted by green light exposure, regulates bone mass through the activation of Gpr147

Yu You
Konglin Huo
Jian Luo
ResearchOpen Access21 Jan 2025
Bone Research

Volume: 13, P: 1-12
LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption

LGR4 has been identified as a new receptor for RANKL in bone cells where it opposes RANK signaling to inhibit osteoclasts differentiation, and its therapeutic targeting promotes reduced bone loss in three mouse models of osteoporosis.

Jian Luo
Zhengfeng Yang
Mingyao Liu
Research11 Apr 2016
Nature Medicine

Volume: 22, P: 539-546
Targeting complement hyperactivation: a novel therapeutic approach for severe pneumonia induced by influenza virus/staphylococcus aureus coinfection

Leili Jia
Haihua Luo
Hongbin Song
ResearchOpen Access29 Dec 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-4
Genome-wide association analyses identify distinct genetic architectures for age-related macular degeneration across ancestries

Multi-ancestry genome-wide analyses identify new risk loci for age-related macular degeneration. Ancestry-specific analyses identify distinct effects at major risk loci, including smaller effect sizes for CFH risk alleles in haplotypes of African ancestry.

Bryan R. Gorman
Georgios Voloudakis
Sudha K. Iyengar
Research02 Dec 2024
Nature Genetics

Volume: 56, P: 2659-2671
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

Iris Heid, Gonçalo Abecasis, Sudha Iyengar and colleagues report the results of a large genome-wide association meta-analysis of macular degeneration based on over 43,000 subjects. They identify 16 new risk loci, including some very rare coding variants.

Lars G Fritsche
Wilmar Igl
Iris M Heid
Research21 Dec 2015
Nature Genetics

Volume: 48, P: 134-143
PGE2 activates EP4 in subchondral bone osteoclasts to regulate osteoarthritis

Wenhao Jiang
Yunyun Jin
Jian Luo
ResearchOpen Access09 Mar 2022
Bone Research

Volume: 10, P: 1-16
Genetic testing of 248 Chinese aortopathy patients using a panel assay

Hang Yang
Mingyao Luo
Zhou Zhou
ResearchOpen Access09 Sept 2016
Scientific Reports

Volume: 6, P: 1-8
A novel prostaglandin E receptor 4 (EP4) small molecule antagonist induces articular cartilage regeneration

Yunyun Jin
Qianqian Liu
Jian Luo
ResearchOpen Access08 Mar 2022
Cell Discovery

Volume: 8, P: 1-22
Single-cell RNA sequencing identifies an Il1rn⁺/Trem1⁺ macrophage subpopulation as a cellular target for mitigating the progression of thoracic aortic aneurysm and dissection

Xuanyu Liu
Wen Chen
Zhou Zhou
ResearchOpen Access08 Feb 2022
Cell Discovery

Volume: 8, P: 1-21
The role of GPCRs in bone diseases and dysfunctions

Jian Luo
Peng Sun
Jianru Xiao
ReviewsOpen Access08 Jul 2019
Bone Research

Volume: 7, P: 1-19
Inhibition of Osteoclastogenesis and Bone Resorption in vitro and in vivo by a prenylflavonoid xanthohumol from hops

Jing Li
Li Zeng
Mingyao Liu
ResearchOpen Access01 Dec 2015
Scientific Reports

Volume: 5, P: 1-14
A transcriptome-wide association study based on 27 tissues identifies 106 genes potentially relevant for disease pathology in age-related macular degeneration

Tobias Strunz
Susette Lauwen
Bernhard H. F. Weber
ResearchOpen Access31 Jan 2020
Scientific Reports

Volume: 10, P: 1-16
Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes

Wenbin Ma
Chunzhi Xia
Mingyao Liu
Research29 Mar 2001
Oncogene

Volume: 20, P: 1703-1714

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Author Correction: Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src

Scaling up spatial transcriptomics for large-sized tissues: uncovering cellular-level tissue architecture beyond conventional platforms with iSCALE

Leveraging deep single-soma RNA sequencing to explore the neural basis of human somatosensation

Spatial transcriptomics reveals human cortical layer and area specification

Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src

GnIH secreted by green light exposure, regulates bone mass through the activation of Gpr147

LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption

Targeting complement hyperactivation: a novel therapeutic approach for severe pneumonia induced by influenza virus/staphylococcus aureus coinfection

Genome-wide association analyses identify distinct genetic architectures for age-related macular degeneration across ancestries

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

PGE2 activates EP4 in subchondral bone osteoclasts to regulate osteoarthritis

Genetic testing of 248 Chinese aortopathy patients using a panel assay

A novel prostaglandin E receptor 4 (EP4) small molecule antagonist induces articular cartilage regeneration

Single-cell RNA sequencing identifies an Il1rn⁺/Trem1⁺ macrophage subpopulation as a cellular target for mitigating the progression of thoracic aortic aneurysm and dissection

The role of GPCRs in bone diseases and dysfunctions

Inhibition of Osteoclastogenesis and Bone Resorption in vitro and in vivo by a prenylflavonoid xanthohumol from hops

A transcriptome-wide association study based on 27 tissues identifies 106 genes potentially relevant for disease pathology in age-related macular degeneration

Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes

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