The transcription factor and tumor suppressor p53 is central to many stress responses and is the target of multiple regulators. The regulatory subunit of PI3 kinase, p85α and CDC42 are now both found to be targets of the miR-29 microRNAs. As p85α and CDC42 are repressors of p53, these miRNAs indirectly activate p53 and thus apoptosis.
- Seong-Yeon Park
- Jung Hyun Lee
- V Narry Kim
