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Showing 1–4 of 4 results
Advanced filters: Author: Minlong Wang Clear advanced filters

  • Disulfide bonds are widely found in nature and are prevalent in therapeutic contexts due to their dynamic nature. Here, the authors disclose a click chemistry protocol to convert thiols to disulfides using SO2F2, and show its application in aqueous contexts, in flow, and for polymerizations.

    • Hengzhao Li
    • Mengqi Peng
    • Jie An
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-9

  • Establishing efficient covalent linkages between functional organic molecules and inorganic materials remains a significant challenge. Herein, the authors report an intramolecular chalcogen bonding activated SuFEx click chemistry and establish a clickable platform for the efficient linkage of organic compounds and inorganic materials.

    • Minlong Wang
    • Jiaman Hou
    • Jie An
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12

  • H3K27me3 binding to the EED pocket of the Polycomb repressive complex 2 (PRC2) is required to activate PRC2. An allosteric small-molecule inhibitor of PRC2 was identified that binds to the EED pocket and blocks PRC2 methyltransferase activity in cells.

    • Wei Qi
    • Kehao Zhao
    • En Li
    Research
    Nature Chemical Biology
    Volume: 13, P: 381-388