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Regulation of BRCA1 stability through the tandem UBX domains of isoleucyl-tRNA synthetase 1

Aminoacyl-tRNA synthetases possess unique domains. In this study the structure of the vertebrate IARS1 and EARS1 complex reveals that vertebrate IARS1 protects the DNA repair factor BRCA1 from proteolytic degradation via its UBX-fold domain.

Scisung Chung
Mi-Sun Kang
Yunje Cho
ResearchOpen Access08 Nov 2022
Nature Communications

Volume: 13, P: 1-14
ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress

How the replisome machinery contributes to fork stability under replication stress is currently not clear. Here the authors reveal a role for ATAD5 in maintaining genome integrity during replication stress by promoting replication restart through RAD51/PCNA regulation.

Su Hyung Park
Nalae Kang
Kyungjae Myung
ResearchOpen Access16 Dec 2019
Nature Communications

Volume: 10, P: 1-15

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Regulation of BRCA1 stability through the tandem UBX domains of isoleucyl-tRNA synthetase 1

ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress

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