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Showing 1–12 of 12 results
Advanced filters: Author: Minzhe Guo Clear advanced filters

  • Tandem electro-biocatalytic systems present a versatile platform for producing a variety of synthetic products using CO2 as a starting material. Here direct ocean carbon capture is incorporated into an electrolysis scheme to produce formic acid from CO2 dissolved in seawater that is subsequently converted to succinate in a bioreactor.

    • Chengbo Li
    • Mingming Guo
    • Chuan Xia
    Research
    Nature Catalysis
    P: 1-15

  • Accurate cell-type identification is vital for single-cell analysis. Here, the authors develop a computational pipeline called “LungMAP CellRef” for efficient, automated cell-type annotation of normal and disease human and mouse lung single-cell datasets.

    • Minzhe Guo
    • Michael P. Morley
    • Yan Xu
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-20

  • Z. Liu, Y. Liu and Z. Yu et al. discovered a subtype of valve interstitial cells underneath the valve endothelial cells sensing unidirectional flow. These cells express high levels of APOE, which is responsible for JAG1–NOTCH2-mediated fetal elastogenesis.

    • Ziyi Liu
    • Yu Liu
    • Mingxia Gu
    Research
    Nature Cardiovascular Research
    Volume: 3, P: 933-950

  • Mutations in FOXF1, a key transcriptional regulator of pulmonary vascular development, cause Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins. Here, the authors discovered four genomic regions that control cell type-specific activity of Foxf1 during lung development and show that disrupting these regions via genetic deletions leads to alveolar capillary dysplasia.

    • Guolun Wang
    • Bingqiang Wen
    • Vladimir V. Kalinichenko
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • Growth and differentiation of pulmonary epithelial cells is precisely controlled to form the alveoli that create the gas exchange region of the lung. Here, the authors demonstrate that epigenetic modulation of the genome by PRDM3/16 mediates NKX2-1 activity to control alveolar cell fate and differentiation during embryonic and perinatal lung development.

    • Hua He
    • Sheila M. Bell
    • Jeffrey A. Whitsett
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • The respiratory system is transformed in terms of functional change at birth to adapt to breathing air. Here, the authors examine the molecular changes behind the first breath in the mouse by Drop-seq based RNA sequencing, identifying activation of the unfolded protein response as a perinatal adaptation of the lung.

    • Minzhe Guo
    • Yina Du
    • Yan Xu
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • A single-cell atlas of the human lungs, integrating data from 2.4 million cells from 486 individuals and including samples from healthy and diseased lungs, provides a roadmap for the generation of organ-scale cell atlases.

    • Lisa Sikkema
    • Ciro Ramírez-Suástegui
    • Fabian J. Theis
    ResearchOpen Access
    Nature Medicine
    Volume: 29, P: 1563-1577

  • An integrated analysis of over 100 single-cell and single-nucleus transcriptomics studies illustrates severe acute respiratory syndrome coronavirus 2 viral entry gene coexpression patterns across different human tissues, and shows association of age, smoking status and sex with viral entry gene expression in respiratory cell populations.

    • Christoph Muus
    • Malte D. Luecken
    • Xiaohui Zhang
    Research
    Nature Medicine
    Volume: 27, P: 546-559

  • The transcription factor NKX2-1 is a key regulator of lung pathophysiology, but the importance of its binding sites outside of proximal promoter regions is unclear. Here, William Stuart and Iris Fink-Baldauf et al. use CRISPRi to interrogate 19 NKX2-1 binding sites and identify specific sites important for breathing, innate immune defense, and tumorigenesis.

    • William D. Stuart
    • Iris M. Fink-Baldauf
    • Yutaka Maeda
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-14