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Showing 1–3 of 3 results
Advanced filters: Author: Mirela Andronescu Clear advanced filters

  • The topologies of, and spatial relationships between, chromosomes are important but poorly understood. Here, a high-throughput method is used to study intra- and inter-chromosomal interactions in Saccharomyces cerevisiae. A map of the haploid genome is generated at kilobase resolution, and is used to construct a three-dimensional model of the yeast genome. The findings provide a glimpse of the interface between the form and function of a eukaryotic genome.

    • Zhijun Duan
    • Mirela Andronescu
    • William S. Noble
    Research
    Nature
    Volume: 465, P: 363-367

  • Gene fitness and essentiality analyses using in vivo cancer models are challenging due to multiple confounders. Here, the authors develop a quantitative approach to study CRISPR-transduced patient-derived xenografts, which they use to analyse in vivo gene fitness in breast cancers and the biological features that influence uncertainty in fitness estimation.

    • Peter Eirew
    • Ciara O’Flanagan
    • Samuel Aparicio
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-19