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Showing 1–4 of 4 results
Advanced filters: Author: Miriam Cipullo Clear advanced filters

  • Mitochondrial ribosomes (mitoribosomes) are characterized by a distinct architecture and thus biogenesis pathway. Here, cryo-EM structures of mitoribosome large subunit assembly intermediates elucidate final steps of 16 S rRNA folding, methylation and peptidyl transferase centre (PTC) completion, as well as functions of several mitoribosome assembly factors.

    • Miriam Cipullo
    • Genís Valentín Gesé
    • Joanna Rorbach
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • Here, using long-read RNA sequencing, SILAC proteomics, and cryo-EM, the authors show that loss of mitochondrial methylation impairs rRNA processing and ribosome maturation, leading to unprocessed rRNA accumulation and defective monosome assembly.

    • Ruth I. C. Glasgow
    • Vivek Singh
    • Anna Wredenberg
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • Multiple GTP-binding proteins (GTPBPs) aid ribosome maturation. Here, authors pinpoint GTPBP8’s involvement in human mitoribosome maturation, demonstrating its specific binding to mitoribosomal large subunit RNA, which is necessary for ribosome assembly and protein synthesis.

    • Miriam Cipullo
    • Genís Valentín Gesé
    • Joanna Rorbach
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Structural analysis of several small mitoribosomal subunit intermediates reveals a sequential mechanism of biogenesis, and how assembly links to initiation to form active mitoribosomes.

    • Yuzuru Itoh
    • Anas Khawaja
    • Alexey Amunts
    ResearchOpen Access
    Nature
    Volume: 606, P: 603-608