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Showing 1–2 of 2 results
Advanced filters: Author: Miriam Damm Clear advanced filters
  • PHD3 is a hypoxia-inducible prolyl hydroxylase that regulates stability of HIF-1. Here Garvalov et al.report a hydroxylase-independent role of PHD3 in gliomas as a scaffolding protein that promotes internalization and limits signalling of EGFR upon ligand binding, thus inhibiting growth in hypoxia.

    • Boyan K. Garvalov
    • Franziska Foss
    • Till Acker
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-11