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Showing 1–12 of 12 results
Advanced filters: Author: Miroslav Radman Clear advanced filters
  • Deinococcus radiodurans is able to withstand high doses of radiation, despite the DNA damage caused. Genome fragments with regions of complementary sequence meet and initiate synthesis by a DNA polymerase to form long single-stranded ends on the fragments. The complementary single-strand tails then pair and regenerate long double-stranded DNA molecules that are processed into the original circular genome.

    • Ksenija Zahradka
    • Dea Slade
    • Miroslav Radman
    Research
    Nature
    Volume: 443, P: 569-573
  • Artificial evolution implements the rules of natural evolution in algorithms that aim to solve biological and computational problems. The authors propose a new discipline, computational evolution, that replaces the outdated principles of artificial evolution with a modern understanding of biology.

    • Wolfgang Banzhaf
    • Guillaume Beslon
    • Jeremy J. Ramsden
    Reviews
    Nature Reviews Genetics
    Volume: 7, P: 729-735
  • Although many mutations are harmful, some can help a population to adapt to environmental changes and enhance its chances of survival. Mutations have always been thought to be random, chance events, but the discovery of a set of enzymes known as mutases indicates that cells have mechanisms for generating them. The process needs to be tightly regulated, though, and is switched on only when the cell is under stress.

    • Miroslav Radman
    News & Views
    Nature
    Volume: 401, P: 866-869
  • Atomically precise gold nanoclusters hold promise as non-linear optical probes for biological imaging. Here functionalized luminescent gold nanoclusters bind free carbonyls via oxime bond formation, allowing detection of carbonylated proteins via gel electrophoresis and fluorescence imaging.

    • Guillaume F. Combes
    • Hussein Fakhouri
    • Rodolphe Antoine
    ResearchOpen Access
    Communications Chemistry
    Volume: 4, P: 1-11
  • Studies on model organisms have led to crucial advances in understanding the molecular processes that are involved in repairing DNA double-strand breaks. These have been complemented and extended by the molecular dissection of human disorders in which double-strand break repair is compromised.

    • Mark O'Driscoll
    • Penny A. Jeggo
    Reviews
    Nature Reviews Genetics
    Volume: 7, P: 45-54
  • Transcriptional mutagenesis is a process by which RNA polymerases produce mutated transcripts from bypassing certain lesions in the DNA. This Perspective discusses how this might occur in tumour cells to contribute to the mutator phenotype.

    • Damien Brégeon
    • Paul W. Doetsch
    Reviews
    Nature Reviews Cancer
    Volume: 11, P: 218-227