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Showing 1–6 of 6 results

Advanced filters: Author: Mohamed Belal Hamed Clear advanced filters

A small molecule allosterically activates SecA dependent secretion

A small molecule that binds on SecA uncouples activation of the translocase from preprotein binding, transforming the Sec translocase into a promiscuous nanomachine that lost client selectivity and secretes any unfolded protein in vivo or in vitro.

Haitham Sedky
Mohamed Belal Hamed
Anastassios Economou
ResearchOpen Access06 Feb 2026
Communications Biology

P: 1-12
Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Jiyeon Oh
Soeun Kim
Dong Keon Yon
Research06 Jan 2026
Nature Medicine

Volume: 32, P: 197-223
A multinational cross-sectional study on the prevalence and predictors of long COVID across 33 countries

Mohamed Sayed Zaazouee
Eman Ayman Nada
Mohamed Onyango
ResearchOpen Access03 Aug 2025
Scientific Reports

Volume: 15, P: 1-13
Apo and Aβ46-bound γ-secretase structures provide insights into amyloid-β processing by the APH-1B isoform

Incomplete proteolysis of amyloid-β (Aβ) peptides by γ-secretases is linked to Alzheimer’s disease. Using cryo-EM and functional analyses, this study uncovers the γ-secretase – Aβ46 structure and unveils key interactions for efficient Aβ cleavage.

Ivica Odorčić
Mohamed Belal Hamed
Rouslan G. Efremov
ResearchOpen Access27 May 2024
Nature Communications

Volume: 15, P: 1-14
The p.Gly2019Ser is a common LRRK2 pathogenic variant among Egyptians with familial and sporadic Parkinson’s disease

Martina B. William
Sharifa Hamed
Mie Rizig
ResearchOpen Access06 Nov 2024
npj Parkinson's Disease

Volume: 10, P: 1-9
Callus organoids reveal distinct cartilage to bone transition mechanisms across donors and a role for biological sex

Isaak Decoene
Hanna Svitina
Ioannis Papantoniou
ResearchOpen Access26 Mar 2025
Bone Research

Volume: 13, P: 1-16