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Showing 1–5 of 5 results
Advanced filters: Author: Mohamed Trebak Clear advanced filters

  • The essential role of ORAI1 channels in receptor-evoked Ca2+ signaling is well understood, but the roles of ORAI2 and ORAI3 remained obscure. Here authors show that ORAI2 and ORAI3 channels multimerize with ORAI1 to expand the range of sensitivity of receptor-activated Ca2+ signals, reflecting their enhanced basal STIM1-binding and heightened Ca2+-dependent inactivation.

    • Ryan E. Yoast
    • Scott M. Emrich
    • Mohamed Trebak
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • ORAI1 constitutes the store-operated Ca2+ release-activated Ca2+ (CRAC) channel, but how this channel is turned off through Ca2+-dependent inactivation (CDI) remained unclear. Here the authors identify a spatially-restricted Ca2+/cAMP signaling crosstalk critical for mediating CDI which in turn regulates cellular Ca2+ signals and NFAT activation.

    • Xuexin Zhang
    • Trayambak Pathak
    • Mohamed Trebak
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • How plasma membrane Orai Ca2+ channels are activated by STIM proteins to activate Ca2+signals is still not fully known. Here the authors show that a nexus region located at the Orai1 C-terminus allows channel gating without a direct interaction of STIM1 with the channel pore.

    • Yandong Zhou
    • Xiangyu Cai
    • Donald L. Gill
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • Regulated calcium signalling, in particular downstream of the T cell receptor, is crucial for many T cell effector functions. This Review provides an overview of the numerous membrane and organellar calcium-permeable channels that are coordinated to fine-tune T cell immunity.

    • Mohamed Trebak
    • Jean-Pierre Kinet
    Reviews
    Nature Reviews Immunology
    Volume: 19, P: 154-169