Nature Search

Development of a brain-penetrant G9a methylase inhibitor to target Alzheimer’s disease-associated proteopathology

The authors describe a new mechanism of AD pathogenesis in which the histone methylase G9a regulates translation of hippocampal proteins associated with AD pathology. Targeting this mechanism with a brain-penetrant inhibitor of G9a helped rescue brain pathology in AD mouse models.

Ling Xie
Ryan N. Sheehy
Xian Chen
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-18
Caspases: A treatment target for neurodegenerative disease?

Treating neurodegenerative disease with drugs that inhibit the activity of caspases (proteases that regulate apoptosis) is a therapeutic avenue beginning to be explored.

David M. Holtzman
Mohanish Deshmukh
News & Views01 Sept 1997
Nature Medicine

Volume: 3, P: 954-955
miR-29 is an important driver of aging-related phenotypes

A miRNA screen identifies miR-29 as a driver for aging. Expression of miR-29 is sufficient to accelerate aging while its reduction delays aging in mouse models and transcriptomics reveals miR-29-regulated pathways associated with aging.

Vijay Swahari
Ayumi Nakamura
Mohanish Deshmukh
ResearchOpen Access27 Aug 2024
Communications Biology

Volume: 7, P: 1-11
Distinct pathways mediate axon degeneration during apoptosis and axon-specific pruning

Recent studies suggest that there is an overlap between neuronal apoptosis and axon-specific degeneration. Cusack and colleagues show that the caspase-dependent pathways mediating axon degeneration during apoptosis are distinct from those mediating localized axon pruning.

Corey L. Cusack
Vijay Swahari
Mohanish Deshmukh
Research21 May 2013
Nature Communications

Volume: 4, P: 1-11
Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c

Neurons and cancer cells metabolize glucose extensively. Intracellular gluthatione produced by this metabolic pathway reduces cytochrome c release from mitochondria to increase cell survival.

Allyson E. Vaughn
Mohanish Deshmukh
Research23 Nov 2008
Nature Cell Biology

Volume: 10, P: 1477-1483
Apoptosis signaling is activated as a transient pulse in neurons

Keeley L. Spiess
Matthew J. Geden
Mohanish Deshmukh
Research26 Oct 2024
Cell Death & Differentiation

Volume: 32, P: 521-529
p53 is required for nuclear but not mitochondrial DNA damage-induced degeneration

Matthew J. Geden
Selena E. Romero
Mohanish Deshmukh
ResearchOpen Access20 Jan 2021
Cell Death & Disease

Volume: 12, P: 1-11
Characterization of a Cul9–Parkin double knockout mouse model for Parkinson’s disease

Emilie Hollville
Valerie Joers
Mohanish Deshmukh
ResearchOpen Access09 Oct 2020
Scientific Reports

Volume: 10, P: 1-13
ASC deficiency suppresses proliferation and prevents medulloblastoma incidence

E R W Knight
E Y Patel
M Deshmukh
Research27 Jan 2014
Oncogene

Volume: 34, P: 394-402
Apoptotic cell death in disease—Current understanding of the NCCD 2023

Ilio Vitale
Federico Pietrocola
Lorenzo Galluzzi
Reviews26 Apr 2023
Cell Death & Differentiation

Volume: 30, P: 1097-1154
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Lorenzo Galluzzi
Ilio Vitale
Guido Kroemer
ReviewsOpen Access23 Jan 2018
Cell Death & Differentiation

Volume: 25, P: 486-541
Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases

Niamh M. C. Connolly
Pierre Theurey
Jochen H. M. Prehn
ReviewsOpen Access11 Dec 2017
Cell Death & Differentiation

Volume: 25, P: 542-572
Mature neurons: equipped for survival

A J Kole
R P Annis
M Deshmukh
ReviewsOpen Access27 Jun 2013
Cell Death & Disease

Volume: 4, P: e689
Essential postmitochondrial function of p53 uncovered in DNA damage-induced apoptosis in neurons

A E Vaughn
M Deshmukh
Research12 Jan 2007
Cell Death & Differentiation

Volume: 14, P: 973-981
Apoptosome dependent caspase-3 activation pathway is non-redundant and necessary for apoptosis in sympathetic neurons

K M Wright
A E Vaughn
M Deshmukh
Research25 Aug 2006
Cell Death & Differentiation

Volume: 14, P: 625-633
Endoplasmic reticulum stress-induced apoptosis requires bax for commitment and Apaf-1 for execution in primary neurons

M I Smith
M Deshmukh
Research12 Jan 2007
Cell Death & Differentiation

Volume: 14, P: 1011-1019

Search

Development of a brain-penetrant G9a methylase inhibitor to target Alzheimer’s disease-associated proteopathology

Caspases: A treatment target for neurodegenerative disease?

miR-29 is an important driver of aging-related phenotypes

Distinct pathways mediate axon degeneration during apoptosis and axon-specific pruning

Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c

Apoptosis signaling is activated as a transient pulse in neurons

p53 is required for nuclear but not mitochondrial DNA damage-induced degeneration

Characterization of a Cul9–Parkin double knockout mouse model for Parkinson’s disease

ASC deficiency suppresses proliferation and prevents medulloblastoma incidence

Apoptotic cell death in disease—Current understanding of the NCCD 2023

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases

Mature neurons: equipped for survival

Essential postmitochondrial function of p53 uncovered in DNA damage-induced apoptosis in neurons

Apoptosome dependent caspase-3 activation pathway is non-redundant and necessary for apoptosis in sympathetic neurons

Endoplasmic reticulum stress-induced apoptosis requires bax for commitment and Apaf-1 for execution in primary neurons

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