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Showing 1–7 of 7 results
Advanced filters: Author: Moira A. McMahon Clear advanced filters

  • Guide RNA-mediated CRISPR–Cas nucleases are a powerful technology for the engineering of mammalian genomes. CRISPR–Cas9-dependent editing of mutated genes that cause Huntington disease and fragile X syndrome was recently achieved in cell-based models, heralding the first step towards developing this technology into viable therapeutics for neurological diseases.

    • Moira A. McMahon
    • Don W. Cleveland
    News & Views
    Nature Reviews Neurology
    Volume: 13, P: 7-9

  • Siliciano and his colleagues propose a new index for measuring the antiviral activity of anti-HIV drugs in vitro, which suggests that there are limitations to the efficacy of antiviral drugs on the basis of their mechanism of action. They suggest that the new index is a more accurate way of measuring antiviral activity and that it correlates well with clinical outcomes.

    • Lin Shen
    • Susan Peterson
    • Robert F Siliciano
    Research
    Nature Medicine
    Volume: 14, P: 762-766

  • Engineered nucleases have advanced the field of gene therapy with the promise of targeted genome modification as a treatment for human diseases. Here we discuss why engineered nucleases are an exciting research tool for gene editing and consider their applications to a range of biological questions.

    • Moira A McMahon
    • Meghdad Rahdar
    • Matthew Porteus
    Comments & Opinion
    Nature Methods
    Volume: 9, P: 28-31

  • The mitotic checkpoint complex (MCC) is assembled during both mitosis and interphase. Here, the authors use auxin-inducible degron tags to rapidly degrade TRIP13 and find that mitotic exit requires MCC disassembly by TRIP13-catalyzed removal of Mad2 or APC1-driven ubiquitination of Cdc20.

    • Dong Hyun Kim
    • Joo Seok Han
    • Don W. Cleveland
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11