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Showing 1–5 of 5 results

Advanced filters: Author: Mojdeh Shakiba Clear advanced filters

Macrophages and fibroblasts as regulators of the immune response in pancreatic cancer

In this Review, Shakiba and Tuveson provide an overview of the heterogeneity of cancer-associated fibroblasts and tumor-associated macrophages and how they collaborate to establish an immunosuppressive microenvironment in pancreatic ductal adenocarcinoma.

Mojdeh Shakiba
David A. Tuveson
Reviews22 Apr 2025
Nature Immunology

Volume: 26, P: 678-691
An autoimmune stem-like CD8 T cell population drives type 1 diabetes

A population of β-cell-specific autoimmune stem-like CD8 T cells initiates and sustains β-cell destruction and disease in a mouse model of type 1 diabetes.

Sofia V. Gearty
Friederike Dündar
Andrea Schietinger
Research30 Nov 2021
Nature

Volume: 602, P: 156-161
Chromatin states define tumour-specific T cell dysfunction and reprogramming

Epigenetic programming of T cells in solid tumours from a functional to a dysfunctional state occurs in two phases, and only the first phase is reversible.

Mary Philip
Lauren Fairchild
Andrea Schietinger
Research17 May 2017
Nature

Volume: 545, P: 452-456
TOX is a critical regulator of tumour-specific T cell differentiation

The nuclear factor TOX is highly expressed in antigen-specific dysfunctional T cells in tumours and exhausted T cells during chronic viral infection and is a crucial regulator of the differentiation of tumour-specific T cells.

Andrew C. Scott
Friederike Dündar
Andrea Schietinger
Research17 Jun 2019
Nature

Volume: 571, P: 270-274
In situ conversion of porphyrin microbubbles to nanoparticles for multimodality imaging

On exposure to low-frequency ultrasound, porphyrin microbubbles form nanoparticles that possess the same optical and therapeutic properties as the original microbubble, which can be used simultaneously for imaging and drug delivery.

Elizabeth Huynh
Ben Y. C. Leung
Gang Zheng
Research30 Mar 2015
Nature Nanotechnology

Volume: 10, P: 325-332