Nature Search

High-frequency genome editing using ssDNA oligonucleotides with zinc-finger nucleases

Single-stranded oligonucleotides are used as donor templates for zinc-finger nucleases to create targeted genomic deletions and mutations in mammalian cell lines.

Fuqiang Chen
Shondra M Pruett-Miller
Gregory D Davis
Research17 Jul 2011
Nature Methods

Volume: 8, P: 753-755
A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling

One of four papers establishing certain PHD domains as effectors of trimethylated histone H3K4, a chromatin mark generally associated with active transcription. This paper shows that the interaction of H3K4me3 with the PHD finger of an ATP-dependent chromatin remodelling complex is involved in control of Hox gene expression during Xenopus development.

Joanna Wysocka
Tomek Swigut
C. David Allis
Research21 May 2006
Nature

Volume: 442, P: 86-90
AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion

Glioblastomas (GBMs) are highly invasive brain tumours, but the underlying mechanisms of GBM invasion are unclear. Here, the authors perform an RNA interference screen and identify AN1-Type Zinc Finger protein 3 (ZFAND3) as a regulator of GBM invasion, and find that it acts through the transcriptional regulation of invasion-related genes.

Anne Schuster
Eliane Klein
Simone P. Niclou
ResearchOpen Access11 Dec 2020
Nature Communications

Volume: 11, P: 1-16
Exploring the effects of three-finger toxins from Naja ashei venom on neuronal and immunological cancer cell membranes

Barbara Dyba
Elżbieta Rudolphi-Szydło
Konrad Kamil Hus
ResearchOpen Access10 Aug 2024
Scientific Reports

Volume: 14, P: 1-12
Construction and testing of engineered zinc-finger proteins for sequence-specific modification of mtDNA

Michal Minczuk
Paulina Kolasinska-Zwierz
Monika A Papworth
Protocols04 Feb 2010
Nature Protocols

Volume: 5, P: 342-356
Revealing the biophysics of lamina-associated domain formation by integrating theoretical modeling and high-resolution imaging

This study presents a framework combining theory and super-resolution imaging to uncover how chromatin-lamina interactions reorganize the genome across diverse microenvironments and regulate cell identity through molecular mechanisms.

Monika Dhankhar
Zixian Guo
Vivek B. Shenoy
ResearchOpen Access25 Aug 2025
Nature Communications

Volume: 16, P: 1-20
Deciphering the allosteric regulation of mycobacterial inosine-5′-monophosphate dehydrogenase

Here, Bulvas et al use biochemical and cryo-EM techniques to profile the regulatory mechanisms of the essential mycobacterial enzyme IMPDH. They show how GTP and (p)ppGpp nucleotides inhibit IMPDH by locking it in an inactive state.

Ondřej Bulvas
Zdeněk Knejzlík
Iva Pichová
ResearchOpen Access06 Aug 2024
Nature Communications

Volume: 15, P: 1-14
Large-scale transcriptomic analyses reveal downstream target genes of ZFY1 and ZFY2 transcription factors in male germ cells

Hayden Holmlund
Manon Coulée
Monika A. Ward
ResearchOpen Access27 Aug 2025
Cell Death & Differentiation

P: 1-19
Deep sequencing reveals 50 novel genes for recessive cognitive disorders

Hossein Najmabadi
Hao Hu
H. Hilger Ropers
Research21 Sept 2011
Nature

Volume: 478, P: 57-63
Force prediction in the cylindrical grip for a model of hand prosthesis

Ewelina Drelich
Jan Tracz
Witold Rządkowski
ResearchOpen Access11 Oct 2023
Scientific Reports

Volume: 13, P: 1-19
Analysis of protein-DNA interactions in chromatin by UV induced cross-linking and mass spectrometry

Cross-linking mass spectrometry (XLMS) allows mapping of protein-protein and protein-RNA interactions, but the analysis of protein-DNA complexes remains challenging. Here, the authors develop a UV light-based XLMS workflow to determine protein-DNA interfaces in reconstituted chromatin and isolated nuclei.

Alexandra Stützer
Luisa M. Welp
Henning Urlaub
ResearchOpen Access16 Oct 2020
Nature Communications

Volume: 11, P: 1-12
Single-cell and chromatin accessibility profiling reveals regulatory programs of pathogenic Th2 cells in allergic asthma

Pathogenic T helper type 2 cells (pTh2) are involved in allergic asthma and secrete high levels of IL-5 and IL-13. Here, using HDM challenged mice and developing an in vitro pTh2 culture system, the authors investigate the function of epigenetic modifications in pTh2 cells showing that HDAC1 limits the pathogenicity of pTh2 cells and scRNA analysis of these cells indicates two subsets in the lungs.

Matarr Khan
Marlis Alteneder
Nicole Boucheron
ResearchOpen Access15 Mar 2025
Nature Communications

Volume: 16, P: 1-21
Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis

Roquin is an RNA-binding protein that promotes the degradation of specific mRNAs and is crucial for the maintenance of peripheral immune tolerance. Here the authors show that, in addition to its target mRNAs, Roquin can bind miR-146a and the RISC component Ago2 to control homeostasis of both RNA species.

Monika Srivastava
Guowen Duan
Carola G. Vinuesa
ResearchOpen Access20 Feb 2015
Nature Communications

Volume: 6, P: 1-13
Evaluation of physiological response and synchronisation errors during synchronous and pseudosynchronous stimulation trials

Damian Kania
Patrycja Romaniszyn-Kania
Andrzej W. Mitas
ResearchOpen Access16 Apr 2024
Scientific Reports

Volume: 14, P: 1-15
The safety and efficacy of clevidipine for blood pressure management in neurocritical patients: a systematic review and meta-analysis

Monika Widiastuti
Dewi Yulianti Bisri
Iwan Abdul Rachman
ResearchOpen Access16 Mar 2024
Scientific Reports

Volume: 14, P: 1-11
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

ZNRF3 and RNF43 are identified as negative feedback regulators of Wnt signalling; the stem-cell growth factor R-spondin is shown to potentiate Wnt signalling by inhibiting ZNRF3.

Huai-Xiang Hao
Yang Xie
Feng Cong
Research29 Apr 2012
Nature

Volume: 485, P: 195-200
Generation of complex bone marrow organoids from human induced pluripotent stem cells

The authors describe stem cell-derived bone marrow organoids that accurately model the structural and functional properties of the human bone marrow niche.

Stephanie Frenz-Wiessner
Savannah D. Fairley
Christoph Klein
ResearchOpen Access19 Feb 2024
Nature Methods

Volume: 21, P: 868-881
Cardiomyocytes stimulate angiogenesis after ischemic injury in a ZEB2-dependent manner

ZEB2 transcription factor is increased in a subset of cardiomyocytes during stress to induce cardioprotective effects after injury. Here the authors show that therapeutic delivery of ZEB2 prevents cardiac dysfunction after ischemic damage and promotes the activation of pro-angiogenic signals.

Monika M. Gladka
Arwa Kohela
Eva van Rooij
ResearchOpen Access04 Jan 2021
Nature Communications

Volume: 12, P: 1-16
Mutations in NSD1 are responsible for Sotos syndrome, but are not a frequent finding in other overgrowth phenotypes

Seval Türkmen
Gabriele Gillessen-Kaesbach
Denise Horn
Research22 Oct 2003
European Journal of Human Genetics

Volume: 11, P: 858-865
Comparison of near infrared spectroscopy (NIRS) and near-infrared transillumination-backscattering sounding (NIR-T/BSS) methods

Agnieszka Gruszecka
Marcin Gruszecki
Pawel J. Winklewski
ResearchOpen Access29 Oct 2020
Scientific Reports

Volume: 10, P: 1-8
Literature Triage and Indexing in the Mouse Genome Informatics (MGI) Group

Randal Babiuk
Dale Begley
Monika Tomczuk
MultimediaOpen Access14 May 2009
Nature Precedings

P: 1
A transcription factor–based mechanism for mouse heterochromatin formation

The mechanisms that initiate heterochromatin formation and maintain its distinction from euchromatin have remained elusive. However, a new study reveals a pathway in which transcriptional repression of pericentric repeats by sequence-specific transcription factors is essential for the integrity of heterochromatin, thereby considerably expanding the role of transcription factors beyond euchromatic gene regulation.

Aydan Bulut-Karslioglu
Valentina Perrera
Thomas Jenuwein
Research16 Sept 2012
Nature Structural & Molecular Biology

Volume: 19, P: 1023-1030
Barley SIX-ROWED SPIKE3 encodes a putative Jumonji C-type H3K9me2/me3 demethylase that represses lateral spikelet fertility

The VRS genes of barley control the fertility of the lateral spikelets on the barley inflorescence. Here, Bull et al. show that VRS3 encodes a putative Jumonji C-type histone demethylase that regulates expression of other VRS genes, and genes involved in stress, hormone and sugar metabolism.

Hazel Bull
M. Cristina Casao
Robbie Waugh
ResearchOpen Access16 Oct 2017
Nature Communications

Volume: 8, P: 1-9
The transcriptional repressor Nab1 is a specific regulator of pathological cardiac hypertrophy

Monika Buitrago
Kristina Lorenz
Stefan Engelhardt
Research17 Jul 2005
Nature Medicine

Volume: 11, P: 837-844
Translational repression of pre-formed cytokine-encoding mRNA prevents chronic activation of memory T cells

Wolkers and colleagues show that the RNA-binding protein ZFP36L2 represses the translation of pre-formed cytokine-encoding mRNAs in memory T cells.

Fiamma Salerno
Sander Engels
Monika C. Wolkers
Research09 Jul 2018
Nature Immunology

Volume: 19, P: 828-837
The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size

Tchorz and colleagues identify a role for the RSPO–LGR4/5–ZNRF3/RNF43 module as master regulator of Wnt/β-catenin-mediated metabolic liver zonation and hepatic growth/size control during development, homeostasis and regeneration.

Lara Planas-Paz
Vanessa Orsini
Jan S. Tchorz
Research18 Apr 2016
Nature Cell Biology

Volume: 18, P: 467-479
Whole-genome sequencing of patients with rare diseases in a national health system

Whole-genome sequencing and phenotype data sharing are introduced in a national health system to streamline diagnosis and to discover coding and non-coding variants that cause rare diseases.

Ernest Turro
William J. Astle
Willem H. Ouwehand
Research24 Jun 2020
Nature

Volume: 583, P: 96-102
Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences

The genome of the grey short-tailed opossum Monodelphis domestica has been sequenced and analyzed, giving a first peek at a marsupial's genetic code. Of particular interest are the genetics of the immune system, which has been studied as a model for humans, and of the X chromosome for historical reasons.

Tarjei S. Mikkelsen
Matthew J. Wakefield
Kerstin Lindblad-Toh
Research10 May 2007
Nature

Volume: 447, P: 167-177
A longitudinal big data approach for precision health

Personalized omics profiling can lead to actionable health discoveries and stimulate lifestyle changes.

Sophia Miryam Schüssler-Fiorenza Rose
Kévin Contrepois
Michael P. Snyder
Research08 May 2019
Nature Medicine

Volume: 25, P: 792-804
Lévy-like movement patterns of metastatic cancer cells revealed in microfabricated systems and implicated in vivo

Sabil Huda
Bettina Weigelin
Bartosz A. Grzybowski
ResearchOpen Access31 Oct 2018
Nature Communications

Volume: 9, P: 1-11
Dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B

Michael Oldridge
Ana M Fortuna
Andrew O.M. Wilkie
Research01 Mar 2000
Nature Genetics

Volume: 24, P: 275-278
The Influence Of Intrauterine Pressure On Embryo Retention In A Catheter After Embryo Transfer

Małgorzata Kozikowska
Miroslaw Grusza
Cezary Grygoruk
ResearchOpen Access19 Aug 2019
Scientific Reports

Volume: 9, P: 1-5
Structure of the MLL CXXC domain–DNA complex and its functional role in MLL-AF9 leukemia

MLL fusions are linked to leukemias and retain the CXXC domain, which binds unmethylated DNA. The NMR structure of CXXC–DNA now indicates the interactions underlying binding. Mutation of a key residue to a nonbinding form decreases proliferation caused by an MLL-AF9 fusion and leukemias induced by MLL-AF9 expression in mice.

Tomasz Cierpicki
Laurie E Risner
John H Bushweller
Research13 Dec 2009
Nature Structural & Molecular Biology

Volume: 17, P: 62-68
A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer

The formation of blood vessels in tumours, angiogenesis, is a promising target for therapy. Here, the authors show that microRNA192 has anti-angiogenic functions and negatively regulates EGR1 and HOXB9, and that delivery of this microRNA to tumours in vivocan reduce angiogenesis and tumour growth.

Sherry Y. Wu
Rajesha Rupaimoole
Anil K. Sood
ResearchOpen Access04 Apr 2016
Nature Communications

Volume: 7, P: 1-14
A rapid antibody screening haemagglutination test for predicting immunity to SARS-CoV-2 variants of concern

Ertesvåg, Xiao et al. describe a method to evaluate neutralising antibodies to SARS-CoV-2 infection or vaccination, including variants of concern. A second mRNA-vaccine dose results in a broader antibody repertoire in adults, although with reduced cross-reactivity to beta and gamma compared to alpha and delta, particularly in the elderly.

Nina Urke Ertesvåg
Julie Xiao
Rebecca Jane Cox
ResearchOpen Access05 Apr 2022
Communications Medicine

Volume: 2, P: 1-11
Expanding the genetics and phenotypic spectrum of Lysine-specific demethylase 5C (KDM5C): a report of 13 novel variants

Emanuela Leonardi
Maria Cristina Aspromonte
Alessandra Murgia
Research25 Nov 2022
European Journal of Human Genetics

Volume: 31, P: 202-215
Reference gene selection in bovine caruncular epithelial cells under pregnancy-associated hormones exposure

Magdalena Sozoniuk
Monika Jamioł
Krzysztof Kowalczyk
ResearchOpen Access26 Jul 2022
Scientific Reports

Volume: 12, P: 1-9
Novel cardiovascular findings in association with a POMT2 mutation: three siblings with α-dystroglycanopathy

Hugo R Martinez
William J Craigen
John L Jefferies
Research04 Sept 2013
European Journal of Human Genetics

Volume: 22, P: 486-491
Application of custom-designed oligonucleotide array CGH in 145 patients with autistic spectrum disorders

Barbara Wiśniowiecka-Kowalnik
Monika Kastory-Bronowska
Paweł Stankiewicz
Research03 Oct 2012
European Journal of Human Genetics

Volume: 21, P: 620-625
Generation of stable Drosophila cell lines using multicistronic vectors

Monika González
Itziar Martín-Ruíz
James D. Sutherland
ResearchOpen Access31 Aug 2011
Scientific Reports

Volume: 1, P: 1-7
Multiple input algorithm-guided Deep Brain stimulation-programming for Parkinson’s disease patients

Eileen Gülke
León Juárez Paz
Monika Pötter-Nerger
ResearchOpen Access29 Oct 2022
npj Parkinson's Disease

Volume: 8, P: 1-10
Effect of electromagnetic field radiation on transcriptomic profile and DNA methylation level in pig conceptuses during the peri-implantation period

Anita Franczak
Agata Zmijewska
Tiziana L. Brevini
ResearchOpen Access23 Apr 2025
Scientific Reports

Volume: 15, P: 1-21
Factors influencing pain medication and opioid use in patients with musculoskeletal injuries: a retrospective insurance claims database study

Stefan Markus Scholz
Nicolas Fabrice Thalmann
Maria Monika Wertli
ResearchOpen Access23 Jan 2024
Scientific Reports

Volume: 14, P: 1-12
Malleable machines take shape in eukaryotic transcriptional regulation

Monika Fuxreiter
Peter Tompa
Francisco J Asturias
Reviews13 Nov 2008
Nature Chemical Biology

Volume: 4, P: 728-737
The transcription factor STE12 influences growth on several carbon sources and production of dehydroacetic acid (DHAA) in Trichoderma reesei

Miriam Schalamun
Wolfgang Hinterdobler
Monika Schmoll
ResearchOpen Access26 Apr 2024
Scientific Reports

Volume: 14, P: 1-14
Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system

Hemmo Meyer
Monika Bug
Sebastian Bremer
Reviews02 Feb 2012
Nature Cell Biology

Volume: 14, P: 117-123
Transcriptome Analysis of Circulating PBMCs to Understand Mechanism of High Altitude Adaptation in Native Cattle of Ladakh Region

Preeti Verma
Ankita Sharma
Manishi Mukesh
ResearchOpen Access16 May 2018
Scientific Reports

Volume: 8, P: 1-15
Applications of machine learning to diagnosis and treatment of neurodegenerative diseases

In this Review, the authors describe the latest developments in the use of machine learning to interrogate neurodegenerative disease-related datasets. They discuss applications of machine learning to diagnosis, prognosis and therapeutic development, and the challenges involved in analysing health-care data.

Monika A. Myszczynska
Poojitha N. Ojamies
Laura Ferraiuolo
Reviews15 Jul 2020
Nature Reviews Neurology

Volume: 16, P: 440-456
Craniopharyngioma

Craniopharyngiomas are rare malformational intracranial tumours that arise along the craniopharyngeal duct. This Primer describes their formation, diagnosis and treatment, distinguishing between the two histological subtypes — adamantinomatous craniopharyngioma and papillary craniopharyngioma.

Hermann L. Müller
Thomas E. Merchant
Stephanie Puget
Reviews07 Nov 2019
Nature Reviews Disease Primers

Volume: 5, P: 1-19
ERα status of invasive ductal breast carcinoma as a result of regulatory interactions between lysine deacetylases KAT6A and KAT6B

Mateusz Olbromski
Monika Mrozowska
Aleksandra Piotrowska
ResearchOpen Access06 Nov 2024
Scientific Reports

Volume: 14, P: 1-13

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