Nature Search

Mechanism of transformation by v-ErbA: Substitution for steroid hormone receptor function in self renewal induction

Anton Bauer
Eugen Ulrich
Marieke von Lindern
Research07 Aug 1997
Oncogene

Volume: 15, P: 701-715
ETMR stem-like state and chemo-resistance are supported by perivascular cells at single-cell resolution

Embryonal tumour with multilayered rosettes (ETMR) is a rare and aggressive paediatric brain tumour. Here, the authors analyse intratumour heterogeneity and the tumour microenvironment in ETMR using single-cell and spatial transcriptomics, in vitro cultures, and a 3D forebrain organoid model, finding important aspects – such as the communication with pericytes – for ETMR development and response to therapy.

Flavia W. de Faria
Nicole C. Riedel
Kornelius Kerl
ResearchOpen Access25 Jun 2025
Nature Communications

Volume: 16, P: 1-19
Recurrent intragenic rearrangements of EGFR and BRAF in soft tissue tumors of infants

Soft tissue tumors in infants encompass an overlapping spectrum of diseases posing unique diagnostic and clinical challenges. Here, the authors investigate the genetic basis of cryptogenic congenital mesoblastic nephroma and infantile fibrosarcoma lacking the canonical NTRK3-ETV6 fusion gene, and identify therapeutically tractable intragenic rearrangements in EGFR and BRAF.

Jenny Wegert
Christian Vokuhl
Sam Behjati
ResearchOpen Access18 Jun 2018
Nature Communications

Volume: 9, P: 1-6
Single-cell transcriptomics identifies potential cells of origin of MYC rhabdoid tumors

Rhabdoid tumors (RT) are aggressive paediatric cancers with yet unknown cells of origin. Here, the authors establish genetically engineered mouse models of RT and, using single-cell RNA-seq and epigenomics, identify potential cells of origin for the SHH and MYC subtypes.

Monika Graf
Marta Interlandi
Kornelius Kerl
ResearchOpen Access22 Mar 2022
Nature Communications

Volume: 13, P: 1-19
Lack of SMARCB1 expression characterizes a subset of human and murine peripheral T-cell lymphomas

Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) is a heterogeneous and aggressive type of T-cell lymphoma. Here, the authors perform single-cell analyses of human and murine PTCL-NOS tumors, and identify a subtype defined by the loss of SMARCB1 that could be targeted with HDAC-inhibitor combination therapies.

Anja Fischer
Thomas K. Albert
Kornelius Kerl
ResearchOpen Access03 Oct 2024
Nature Communications

Volume: 15, P: 1-18
SARS-CoV-2 evolution during treatment of chronic infection

Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Research05 Feb 2021
Nature

Volume: 592, P: 277-282
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Research11 Mar 2021
Nature

Volume: 593, P: 136-141
Whole-genome sequencing of patients with rare diseases in a national health system

Whole-genome sequencing and phenotype data sharing are introduced in a national health system to streamline diagnosis and to discover coding and non-coding variants that cause rare diseases.

Ernest Turro
William J. Astle
Willem H. Ouwehand
Research24 Jun 2020
Nature

Volume: 583, P: 96-102
GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements

Investigation of variation in three cohorts has identified multiple genetic signals associated with the pregnancy-specific liver disorder, intrahepatic cholestasis of pregnancy, giving insight into the disease which can cause preterm birth and stillbirth.

Peter H. Dixon
Adam P. Levine
Catherine Williamson
ResearchOpen Access17 Aug 2022
Nature Communications

Volume: 13, P: 1-18
SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition

SARS-CoV-2-specific CD4⁺ and CD8⁺ T cell epitopes are found in both convalescent patients and virus-naive volunteers and are indicative of heterologous recognition shared with seasonal cold viruses.

Annika Nelde
Tatjana Bilich
Juliane S. Walz
Research30 Sept 2020
Nature Immunology

Volume: 22, P: 74-85
Whole-genome sequencing of a sporadic primary immunodeficiency cohort

Whole-genome sequencing analysis of individuals with primary immunodeficiency identifies new candidate disease-associated genes and shows how the interplay between genetic variants can explain the variable penetrance and complexity of the disease.

James E. D. Thaventhiran
Hana Lango Allen
Kenneth G. C. Smith
Research06 May 2020
Nature

Volume: 583, P: 90-95
A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol

Haploid genetic screening of cells under different types of mitochondrial perturbation shows that a pathway involving OMA1, DELE1 and the eIF2α kinase HRI communicates mitochondrial stress to the cytosol to trigger the integrated stress response.

Evelyn Fessler
Eva-Maria Eckl
Lucas T. Jae
Research04 Mar 2020
Nature

Volume: 579, P: 433-437
A rather wild imagination: who is and who is not a migrant in the Czech media and society?

Monika Gabriela Bartoszewicz
Otto Eibl
ResearchOpen Access06 Jul 2022
Humanities and Social Sciences Communications

Volume: 9, P: 1-14
Stabilization of modulation instability by control field in semiconductor quantum wells

Monika Nath
Rohit Mukherjee
Nitu Borgohain
ResearchOpen Access11 May 2023
Scientific Reports

Volume: 13, P: 1-11
Upper Palaeolithic Siberian genome reveals dual ancestry of Native Americans

Draft genomes of two south-central Siberian individuals dating to 24,000 and 17,000 years ago show that they are genetically closely related to modern-day western Eurasians and Native Americans but not to east Asians; the results have implications for our understanding of the origins of Native Americans.

Maanasa Raghavan
Pontus Skoglund
Eske Willerslev
Research20 Nov 2013
Nature

Volume: 505, P: 87-91
Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E24
Author Correction: SARS-CoV-2 evolution during treatment of chronic infection

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E23
Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits

Jessica van Setten
Niek Verweij
Aaron Isaacs
ResearchOpen Access24 Jan 2019
European Journal of Human Genetics

Volume: 27, P: 952-962
A complex journey: transmission of microbial symbionts

Transmission of symbionts from one host generation to the next can occur horizontally from the environment or vertically through the host germ line. In this Review, Bright and Bulgheresi detail the molecular mechanisms governing the transmission of a range of symbionts and discuss how transmission mode can shape the evolution of the symbiotic partners.

Monika Bright
Silvia Bulgheresi
Reviews01 Mar 2010
Nature Reviews Microbiology

Volume: 8, P: 218-230
Neurodevelopmental outcome of preterm infants enrolled in myo-inositol randomized controlled trial

Ira Adams-Chapman
Kristi L. Watterberg
Marian Willinger
Research23 Mar 2021
Journal of Perinatology

Volume: 41, P: 2072-2087
Drug sensitivity profiling of 3D tumor tissue cultures in the pediatric precision oncology program INFORM

Heike Peterziel
Nora Jamaladdin
Ina Oehme
ResearchOpen Access27 Dec 2022
npj Precision Oncology

Volume: 6, P: 1-17
Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort

James E. D. Thaventhiran
Hana Lango Allen
Kenneth G. C. Smith
Amendments and Corrections17 Jul 2020
Nature

Volume: 584, P: E2
Differential survival trends of stage II colorectal cancer patients relate to promoter methylation status of PCDH10, SPARC, and UCHL1

Ellen Heitzer
Monika Artl
Nadia Dandachi
Research06 Dec 2013
Modern Pathology

Volume: 27, P: 906-915

Search

Mechanism of transformation by v-ErbA: Substitution for steroid hormone receptor function in self renewal induction

ETMR stem-like state and chemo-resistance are supported by perivascular cells at single-cell resolution

Recurrent intragenic rearrangements of EGFR and BRAF in soft tissue tumors of infants

Single-cell transcriptomics identifies potential cells of origin of MYC rhabdoid tumors

Lack of SMARCB1 expression characterizes a subset of human and murine peripheral T-cell lymphomas

SARS-CoV-2 evolution during treatment of chronic infection

Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Whole-genome sequencing of patients with rare diseases in a national health system

GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements

SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition

Whole-genome sequencing of a sporadic primary immunodeficiency cohort

A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol

A rather wild imagination: who is and who is not a migrant in the Czech media and society?

Stabilization of modulation instability by control field in semiconductor quantum wells

Upper Palaeolithic Siberian genome reveals dual ancestry of Native Americans

Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Author Correction: SARS-CoV-2 evolution during treatment of chronic infection

Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits

A complex journey: transmission of microbial symbionts

Neurodevelopmental outcome of preterm infants enrolled in myo-inositol randomized controlled trial

Drug sensitivity profiling of 3D tumor tissue cultures in the pediatric precision oncology program INFORM

Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort

Differential survival trends of stage II colorectal cancer patients relate to promoter methylation status of PCDH10, SPARC, and UCHL1

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