Torsten Roepke et al. show that the potassium channel subunit KCNE2—which previously has been most recognized for its role in controlling electrical activity in the heart—is important for normal thyroid function. KCNE2, together with its partner KCNQ1, is expressed in both mouse and human thyroid epithelial cells, and Kcne2 deficiency in mice leads to a constellation of defects resulting from decreased thyroid hormone biosynthesis. These results suggest new genetic links between thyroid and heart function.
- Torsten K Roepke
- Elizabeth C King
- Geoffrey W Abbott
