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TGF-β builds a dual immune barrier in colorectal cancer by impairing T cell recruitment and instructing immunosuppressive SPP1⁺ macrophages

Targeting TGFBR1 in transplantable mouse colorectal tumor organoids improves response to anti-PD-L1 therapy. Mechanistically, TGF-β abrogates clonal expansion of T effector and memory phenotypes and indirectly inhibits T cell activity by regulating immunosuppressive tumor-associated macrophage activity.

Ana Henriques
Maria Salvany-Celades
Eduard Batlle
Research07 Nov 2025
Nature Genetics

Volume: 57, P: 3050-3065
TP53INP2 regulates adiposity by activating β-catenin through autophagy-dependent sequestration of GSK3β

Romero et al. show that the autophagy regulator TP53INP2 represses adipogenesis by promoting GSK3β sequestration and activation of β-catenin through an autophagy-dependent and ESCRT-dependent mechanism.

Montserrat Romero
Alba Sabaté-Pérez
Antonio Zorzano
Research28 Mar 2018
Nature Cell Biology

Volume: 20, P: 443-454
Expression of Snail protein in tumor–stroma interface

C Francí
M Takkunen
A García de Herreros
Research27 Mar 2006
Oncogene

Volume: 25, P: 5134-5144
Somatic reversion in CD137 deficiency correlating with Epstein-Barr virus control and clinical improvement

Laura Batlle-Masó
Joan Padrosa Pulido
Roger Colobran
ResearchOpen Access28 Nov 2025
npj Genomic Medicine

Volume: 10, P: 1-8
Publisher Correction: Development and validation of a sample entropy-based method to identify complex patient-ventilator interactions during mechanical ventilation

Leonardo Sarlabous
José Aquino‑Esperanza
Lluís Blanch
Amendments and CorrectionsOpen Access09 Nov 2020
Scientific Reports

Volume: 10, P: 1
Clinical outcomes of allogeneic hematopoietic stem cell transplant recipients developing Cytomegalovirus DNAemia prior to engraftment

Carlos Solano
Lourdes Vázquez
David Navarro
Research15 Dec 2020
Bone Marrow Transplantation

Volume: 56, P: 1281-1290
Aortic remodelling induced by obstructive apneas is normalized with mesenchymal stem cells infusion

Cira Rubies
Ana-Paula Dantas
Eduard Guasch
ResearchOpen Access07 Aug 2019
Scientific Reports

Volume: 9, P: 1-11
Development and validation of a sample entropy-based method to identify complex patient-ventilator interactions during mechanical ventilation

Leonardo Sarlabous
José Aquino-Esperanza
Lluís Blanch
ResearchOpen Access17 Aug 2020
Scientific Reports

Volume: 10, P: 1-12
G-CSF increases the number of peripheral blood dendritic cells CD16+ and modifies the expression of the costimulatory molecule CD86+

C Talarn
A Urbano-Ispizua
E Montserrat
Research20 Mar 2006
Bone Marrow Transplantation

Volume: 37, P: 873-879
Protocol for regional implementation of community-based collaborative management of complex chronic patients

Isaac Cano
Ivan Dueñas-Espín
Josep Roca
ProtocolsOpen Access14 Jul 2017
npj Primary Care Respiratory Medicine

Volume: 27, P: 1-7

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