Many individuals who survive traumatic brain injury (TBI) experience long-term complications. The prevention and management of such complications, however, remain challenging goals for clinicians. Here, Shlosberg and colleague examine the role of blood–brain barrier (BBB) breakdown in the pathophysiology of TBI, particularly in the development of delayed TBI-related conditions. The authors also discuss novel BBB-targeted therapeutic strategies that might be explored to counter or prevent long-term complications in patients.
- Dan Shlosberg
- Mony Benifla
- Alon Friedman
