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Showing 1–3 of 3 results
Advanced filters: Author: Moon-Hyeong Seo Clear advanced filters

  • The binding affinity of a protein for its ligand is governed by the rates of ligand association and dissociation. Here the authors show that intrinsic conformational dynamics of maltose binding protein dictate the ligand dissociation rate, and hence the affinity of the protein for maltose.

    • Moon-Hyeong Seo
    • Jeongbin Park
    • Hak-Sung Kim
    Research
    Nature Communications
    Volume: 5, P: 1-7

  • A high-throughput strategy utilizes a pooled lentiviral approach consisting of a library of 50,000 peptide binding motifs to identify peptide inhibitors of protein-protein interactions that decrease viability in a pancreatic cancer cell line.

    • Satra Nim
    • Jouhyun Jeon
    • Philip M Kim
    Research
    Nature Chemical Biology
    Volume: 12, P: 275-281