This article reports the case of a 50-year-old man who had undergone kidney and pancreas transplantation and developed pancytopenia following treatment with azathioprine. A genotype test for thiopurineS-methyltransferase (TPMT) showed that the patient was homozygous for TPMT*3A, which accounted for the susceptibility to azathioprine-related myelosuppression. The authors discuss the importance of TPMT testing and describe the tools available for monitoring for adverse effects from treatment.
- Pooja Budhiraja
- Mordecai Popovtzer
