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Showing 1–2 of 2 results
Advanced filters: Author: Morgane Bellot Clear advanced filters

  • Technologies that bias GPCR expression for formation of heterodimers show that, when heterodimerized, α2C-AR and AT-1R exhibit atypical Gs-cAMP-PKA signaling upon ligand stimulation compared to either parent receptor expressed alone and mimic activation associated with arterial hypertension.

    • Morgane Bellot
    • Ségolène Galandrin
    • Céline Galés
    Research
    Nature Chemical Biology
    Volume: 11, P: 271-279

  • BRET probes that monitor activation of multiple G protein isoforms reveal that angiotensin II and a biased agonist of the angiotensin II type 1A receptor stabilize distinct receptor conformations associated with different signaling outputs.

    • Aude Saulière
    • Morgane Bellot
    • Céline Galés
    Research
    Nature Chemical Biology
    Volume: 8, P: 622-630