Physico-chemical properties of the cargo as well as the actual conditions during encapsulation interfere during formulation of nanoparticular cargo–carrier systems. We demonstrate altered chain conformations in the different micelles due to different cargo–carrier interactions leading to different localization of model drugs within the carrier. Finally, these changes lead to differences in pharmacokinetics and biodistribution in vivo, showing the relevance of such effects in a translational manner.
- Adrian T Press
- Anuradha Ramoji
- Michael Bauer
