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Showing 1–8 of 8 results
Advanced filters: Author: Moritz Gartlgruber Clear advanced filters

  • Westermann and colleagues define four subtypes of neuroblastoma based on super-enhancer profiles in primary patient samples, which could be linked to distinct clinical outcomes and cell identity characteristics.

    • Moritz Gartlgruber
    • Ashwini Kumar Sharma
    • Frank Westermann
    Research
    Nature Cancer
    Volume: 2, P: 114-128

  • Interactions between germline variants and somatic mutations is a relatively unexplored topic in cancer. Here, in Ewing sarcoma, the authors show that binding of the oncogenic EWSR1-FLI1 fusion transcription factor to a polymorphic enhancer-like DNA element controls MYBL2, whose high expression correlates with prognosis.

    • Julian Musa
    • Florencia Cidre-Aranaz
    • Thomas G. P. Grünewald
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • Alborzinia et al. report that MYCN-amplified neuroblastoma undergoes ferroptosis in the absence of intracellular cysteine, suggesting a combination of cysteine depletion and concomitant GPX4 inactivation as a potential therapeutic approach.

    • Hamed Alborzinia
    • Andrés F. Flórez
    • Frank Westermann
    ResearchOpen Access
    Nature Cancer
    Volume: 3, P: 471-485

  • Alternative lengthening of telomeres (ALT) is associated with a poor outcome in neuroblastoma. Here, the authors find that ALT is associated with mutated ATRX and/or reduced protein abundance, frequent telomeric repeat loci and heterochromatic telomeric chromatin.

    • Sabine A. Hartlieb
    • Lina Sieverling
    • Frank Westermann
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • A single-cell transcriptomic analysis of neuroblastomas and healthy adrenal glands defines cell types and lineage trajectories during different developmental stages. Comparisons with the transcriptomes of neuroblastoma cells show that their transcriptomes most closely resemble those of developing neuroblasts of the adrenal gland.

    • Selina Jansky
    • Ashwini Kumar Sharma
    • Frank Westermann
    Research
    Nature Genetics
    Volume: 53, P: 683-693

  • Alexander Schramm, Johannes Schulte and colleagues characterize 16 paired samples from patients with neuroblastoma at diagnosis and relapse using whole-exome sequencing, mRNA expression profiling, array CGH and DNA methylation analysis. Their data show the frequency, identity and evolution of genetic alterations in neuroblastoma.

    • Alexander Schramm
    • Johannes Köster
    • Johannes H Schulte
    Research
    Nature Genetics
    Volume: 47, P: 872-877

  • In high-risk neuroblastoma cases, gains in chromosome 17q are common. Here, the authors investigate the epigenomics and transcriptomics of neuroblastoma, identifying TBX2 as a core regulatory circuitry component enhancing the reactivation of DREAM targets by MYCN/FOXM1.

    • Bieke Decaesteker
    • Geertrui Denecker
    • Frank Speleman
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17