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Showing 1–3 of 3 results
Advanced filters: Author: Moritz Haneklaus Clear advanced filters

  • Host metabolic reprogramming plays a role in functional responses against pathogens. Here, the authors characterise malonylated proteins in macrophages and show that malonylation of the glycolytic enzyme GAPDH impacts cytokine production by modulating both its enzymatic activity and RNA-binding capacity.

    • Silvia Galván-Peña
    • Richard G. Carroll
    • Luke A. O’Neill
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • Fbw7 is a ubiquitin-ligase, which targets several oncoproteins for proteolysis, and is therefore important for the control and prevention of tumorigenesis. In this study, Arabi and colleagues carry out a proteomic screen of the targets of Fbw7, and identify Nuclear Factor of κ-B2 as a substrate.

    • Azadeh Arabi
    • Karim Ullah
    • Olle Sangfelt
    ResearchOpen Access
    Nature Communications
    Volume: 3, P: 1-11