Nature Search

Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps

Efflux transporters of the RND family confer resistance to multiple antibiotics in Gram-negative bacteria. Here, the authors identify pyridylpiperazine-based compounds that potentiate antibiotic activity in E. coli through allosteric inhibition of its primary RND transporter.

Coline Plé
Heng-Keat Tam
Ruben C. Hartkoorn
ResearchOpen Access10 Jan 2022
Nature Communications

Volume: 13, P: 1-11
Mapping 123 million neonatal, infant and child deaths between 2000 and 2017

A high-resolution, global atlas of mortality of children under five years of age between 2000 and 2017 highlights subnational geographical inequalities in the distribution, rates and absolute counts of child deaths by age.

Roy Burstein
Nathaniel J. Henry
Simon I. Hay
ResearchOpen Access16 Oct 2019
Nature

Volume: 574, P: 353-358
Plasmonic bimetallic two-dimensional supercrystals for H₂ generation

Plasmonic composites have potential for photocatalytic conversions using solar light; however, complex interactions between light and the components are poorly understood. Here, a highly ordered two-dimensional plasmonic bimetallic AuPt supercrystal demonstrates a high rate of H₂ generation from formic acid while providing insight into the interaction between plasmonic antenna and catalyst.

Matias Herran
Sabrina Juergensen
Emiliano Cortés
ResearchOpen Access30 Nov 2023
Nature Catalysis

Volume: 6, P: 1205-1214
Heterogeneity-driven phenotypic plasticity and treatment response in branched-organoid models of pancreatic ductal adenocarcinoma

Branched organoids embedded in collagen gels can recapitulate the phenotypic landscape and pronounced molecular and morphological heterogeneity of pancreatic ductal adenocarcinoma.

Aristeidis Papargyriou
Mulham Najajreh
Maximilian Reichert
ResearchOpen Access10 Dec 2024
Nature Biomedical Engineering

Volume: 9, P: 836-864
Reply to 'Tandem organic solar cells revisited'

Ronny Timmreck
Toni Meyer
Karl Leo
Correspondence31 May 2016
Nature Photonics

Volume: 10, P: 355
PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex

PWWP2A is a chromatin-binding transcriptional regulator that mediates mitosis-progression. Here, the authors provide evidence that PWWP2A directly interacts with H2A.Z nucleosomes, DNA and H3K36me3, binds to an MTA1-specific subcomplex of the NuRD complex (M1HR) and promotes changes to histone acetylation.

Stephanie Link
Ramona M. M. Spitzer
Sandra B. Hake
ResearchOpen Access16 Oct 2018
Nature Communications

Volume: 9, P: 1-16
Mapping routine measles vaccination in low- and middle-income countries

Although progress in the coverage of routine measles vaccination in children in low- and middle-income countries was made during 2000–2019, many countries remain far from the goal of 80% coverage in all districts by 2019.

Alyssa N. Sbarra
Sam Rolfe
Jonathan F. Mosser
ResearchOpen Access16 Dec 2020
Nature

Volume: 589, P: 415-419
CVnCoV and CV2CoV protect human ACE2 transgenic mice from ancestral B BavPat1 and emerging B.1.351 SARS-CoV-2

Emerging SARS-CoV-2 variants with mutations in the spike protein raise concerns regarding vaccine efficacy. Here, the authors show that two spike encoding mRNA vaccines in preclinical and clinical development protect human ACE2 mice from the B.1.351 variant of concern and ancestral B BavPat1.

Donata Hoffmann
Björn Corleis
Martin Beer
ResearchOpen Access30 Jun 2021
Nature Communications

Volume: 12, P: 1-7
Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Fine-scale geospatial mapping of overweight and wasting (two components of the double burden of malnutrition) in 105 LMICs shows that overweight has increased from 5.2% in 2000 to 6.0% in children under 5 in 2017. Although overall wasting decreased over the same period, most countries are not on track to meet the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025.

Damaris K. Kinyoki
Jennifer M. Ross
Simon I. Hay
ResearchOpen Access20 Apr 2020
Nature Medicine

Volume: 26, P: 750-759
Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry

Emelia Benjamin and colleagues report a meta-analysis of genome-wide association study data for atrial fibrillation, a condition associated with stroke and heart failure, in five European community-based cohorts of the CHARGE consortium. They report an association in ZFHX3 to atrial fibrillation, with replication in an independent cohort from the German AF Network.

Emelia J Benjamin
Kenneth M Rice
Jacqueline C M Witteman
Research13 Jul 2009
Nature Genetics

Volume: 41, P: 879-881
Identifying and quantifying two ligand-binding sites while imaging native human membrane receptors by AFM

Functional analysis of membrane proteins would benefit from the combination of imaging with ligand characterisation. Here, Pfreundschuh et al. use specialised atomic force microscopy tips to image and quantify the binding of two ligands at the same time.

Moritz Pfreundschuh
David Alsteens
Daniel J. Müller
ResearchOpen Access12 Nov 2015
Nature Communications

Volume: 6, P: 1-7
The structural basis of Rubisco phase separation in the pyrenoid

The structural basis of the interactions between Rubisco and its intrinsically disordered linker protein provides insight into phase separation within the algal pyrenoid, an organelle responsible for around a third of global CO₂ fixation.

Shan He
Hui-Ting Chou
Martin C. Jonikas
Research23 Nov 2020
Nature Plants

Volume: 6, P: 1480-1490
Iron mineral dissolution releases iron and associated organic carbon during permafrost thaw

Iron minerals trap carbon in permafrost, preventing microbial degradation and release to the atmosphere as CO₂, but the stability of this carbon as permafrost thaws is unclear. Here the authors use nanoscale analyses to show that thaw conditions stimulate Fe-reducing bacteria that trigger carbon release.

Monique S. Patzner
Carsten W. Mueller
Casey Bryce
ResearchOpen Access10 Dec 2020
Nature Communications

Volume: 11, P: 1-11
Altered carbon turnover processes and microbiomes in soils under long-term extremely high CO₂ exposure

High CO₂ concentrations impact the microbial diversity and functions in wetland soils, significantly increasing geogenic C input.

Felix Beulig
Tim Urich
Kirsten Küsel
Research27 Jan 2016
Nature Microbiology

Volume: 1, P: 1-10
FMNL formins boost lamellipodial force generation

Actin polymerization in lamellipodia of cells is regulated by the Arp2/3 complex and FMNL family formins. Here the authors show that both FMNL2 and FMNL3 contribute to lamellipodium protrusion and structure, and abolishing FMNL2/3 reduces protrusion force generation and migration, without affecting Arp2/3 incorporation.

Frieda Kage
Moritz Winterhoff
Klemens Rottner
ResearchOpen Access22 Mar 2017
Nature Communications

Volume: 8, P: 1-16
Imaging G protein–coupled receptors while quantifying their ligand-binding free-energy landscape

A force-distance curve–based atomic force microscopy method is developed and applied to both image and quantify the ligand-binding free-energy landscape of single protease-activated receptor-1 (PAR1) molecules under physiologically relevant conditions.

David Alsteens
Moritz Pfreundschuh
Daniel J Müller
Research13 Jul 2015
Nature Methods

Volume: 12, P: 845-851
Deep sequencing reveals 50 novel genes for recessive cognitive disorders

Hossein Najmabadi
Hao Hu
H. Hilger Ropers
Research21 Sept 2011
Nature

Volume: 478, P: 57-63
GLORIA - A globally representative hyperspectral in situ dataset for optical sensing of water quality

Moritz K. Lehmann
Daniela Gurlin
Linwei Yue
ResearchOpen Access16 Feb 2023
Scientific Data

Volume: 10, P: 1-14
A multimodal comparison of latent denoising diffusion probabilistic models and generative adversarial networks for medical image synthesis

Gustav Müller-Franzes
Jan Moritz Niehues
Daniel Truhn
ResearchOpen Access26 Jul 2023
Scientific Reports

Volume: 13, P: 1-10
Common variants in KCNN3 are associated with lone atrial fibrillation

Patrick Ellinor and colleagues report a genome-wide association study identifying variants in KCNN3 associated to lone atrial fibrillation.

Patrick T Ellinor
Kathryn L Lunetta
Stefan Kääb
Research21 Feb 2010
Nature Genetics

Volume: 42, P: 240-244
Addendum: Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites

Scott E. Lindner
Kristian E. Swearingen
Stefan H. I. Kappe
Amendments and CorrectionsOpen Access06 Jan 2022
Nature Communications

Volume: 13, P: 1-4
High-accuracy neurite reconstruction for high-throughput neuroanatomy

This Technical Report describes an automated algorithm to trace densely labeled neurons and reconstruct their structure, thus providing a new tool in functional connectome analysis.

Moritz Helmstaedter
Kevin L Briggman
Winfried Denk
Research10 Jul 2011
Nature Neuroscience

Volume: 14, P: 1081-1088
Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors

CAR T cells administered intracerebroventricularly or intratumorally exhibit more rapid kinetics, reduced systemic toxicity and greater therapeutic potency as compared to intravenously delivered CAR T cells in atypical teratoid/rhabdoid tumor xenograft mouse models.

Johanna Theruvath
Elena Sotillo
Crystal L. Mackall
Research27 Apr 2020
Nature Medicine

Volume: 26, P: 712-719
Characterization of tandem organic solar cells

Ronny Timmreck
Toni Meyer
Karl Leo
Correspondence30 Jul 2015
Nature Photonics

Volume: 9, P: 478-479
webKnossos: efficient online 3D data annotation for connectomics

webKnossos is a browser-based tracing and annotation tool for 3D electron microscopy data sets that is optimized for seamless data viewing. The tool’s flight-mode view facilitates fast neurite tracing because of its egocentric viewpoint.

Kevin M Boergens
Manuel Berning
Moritz Helmstaedter
Research12 Jun 2017
Nature Methods

Volume: 14, P: 691-694
Ascites’ neutrophil function is significantly impaired in patients with decompensated cirrhosis but can be restored by autologous plasma incubation

Cornelius Engelmann
Christina Becker
Thomas Berg
ResearchOpen Access05 Dec 2016
Scientific Reports

Volume: 6, P: 1-9
Ser/Thr protein kinase PrkC-mediated regulation of GroEL is critical for biofilm formation in Bacillus anthracis

Gunjan Arora
Andaleeb Sajid
Yogendra Singh
ResearchOpen Access07 Mar 2017
npj Biofilms and Microbiomes

Volume: 3, P: 1-12
Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Damaris K. Kinyoki
Jennifer M. Ross
Simon I. Hay
Amendments and CorrectionsOpen Access02 Jul 2020
Nature Medicine

Volume: 26, P: 1308
Gene-gene Interaction Analyses for Atrial Fibrillation

Honghuang Lin
Martina Mueller-Nurasyid
Patrick T. Ellinor
ResearchOpen Access08 Nov 2016
Scientific Reports

Volume: 6, P: 1-9
Atomic force microscopy-based characterization and design of biointerfaces

Atomic force microscopy (AFM)-based approaches enable the characterization and manipulation of biological and synthetic biointerfaces, including tissues, cells, membranes, proteins, nucleic acid and functional materials. In this Review, the advantages and limitations of imaging, sensing, parameterizing and designing biointerfaces using AFM techniques are discussed.

David Alsteens
Hermann E. Gaub
Daniel J. Müller
Reviews14 Mar 2017
Nature Reviews Materials

Volume: 2, P: 1-16
Inter-epitope spacer variation within polytopic L2-based human papillomavirus antigens affects immunogenicity

Yueru Zhang
Filipe Colaco Mariz
Martin Müller
ResearchOpen Access24 Feb 2024
npj Vaccines

Volume: 9, P: 1-11
Data Descriptor: Daily observations of stable isotope ratios of rainfall in the tropics

Niels C. Munksgaard
Naoyuki Kurita
Costijn Zwart
ResearchOpen Access08 Oct 2019
Scientific Reports

Volume: 9, P: 1-7
Correction: CD95 maintains stem cell-like and non-classical EMT programs in primary human glioblastoma cells

Moritz Drachsler
Susanne Kleber
Ana Martin-Villalba
Amendments and CorrectionsOpen Access22 Jul 2020
Cell Death & Disease

Volume: 11, P: 1-2
Metabolic and physiological interdependencies in the Bathymodiolus azoricus symbiosis

Ruby Ponnudurai
Manuel Kleiner
Stephanie Markert
ResearchOpen Access01 Nov 2016
The ISME Journal

Volume: 11, P: 463-477
Multiparametric high-resolution imaging of native proteins by force-distance curve–based AFM

Moritz Pfreundschuh
David Martinez-Martin
Daniel J Muller
Protocols17 Apr 2014
Nature Protocols

Volume: 9, P: 1113-1130
Abdominal fat deposits determined by magnetic resonance imaging in relation to leptin and vaspin levels as well as insulin resistance in the general adult population

F Genske
J-P Kühn
N Friedrich
Research14 Aug 2017
International Journal of Obesity

Volume: 42, P: 183-189
Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis

J Dennemärker
T Lohmüller
T Reinheckel
Research21 Dec 2009
Oncogene

Volume: 29, P: 1611-1621

Search

Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps

Mapping 123 million neonatal, infant and child deaths between 2000 and 2017

Plasmonic bimetallic two-dimensional supercrystals for H₂ generation

Heterogeneity-driven phenotypic plasticity and treatment response in branched-organoid models of pancreatic ductal adenocarcinoma

Reply to 'Tandem organic solar cells revisited'

PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex

Mapping routine measles vaccination in low- and middle-income countries

CVnCoV and CV2CoV protect human ACE2 transgenic mice from ancestral B BavPat1 and emerging B.1.351 SARS-CoV-2

Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry

Identifying and quantifying two ligand-binding sites while imaging native human membrane receptors by AFM

The structural basis of Rubisco phase separation in the pyrenoid

Iron mineral dissolution releases iron and associated organic carbon during permafrost thaw

Altered carbon turnover processes and microbiomes in soils under long-term extremely high CO₂ exposure

FMNL formins boost lamellipodial force generation

Imaging G protein–coupled receptors while quantifying their ligand-binding free-energy landscape

Deep sequencing reveals 50 novel genes for recessive cognitive disorders

GLORIA - A globally representative hyperspectral in situ dataset for optical sensing of water quality

A multimodal comparison of latent denoising diffusion probabilistic models and generative adversarial networks for medical image synthesis

Common variants in KCNN3 are associated with lone atrial fibrillation

Addendum: Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites

High-accuracy neurite reconstruction for high-throughput neuroanatomy

Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors

Characterization of tandem organic solar cells

webKnossos: efficient online 3D data annotation for connectomics

Ascites’ neutrophil function is significantly impaired in patients with decompensated cirrhosis but can be restored by autologous plasma incubation

Ser/Thr protein kinase PrkC-mediated regulation of GroEL is critical for biofilm formation in Bacillus anthracis

Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Gene-gene Interaction Analyses for Atrial Fibrillation

Atomic force microscopy-based characterization and design of biointerfaces

Inter-epitope spacer variation within polytopic L2-based human papillomavirus antigens affects immunogenicity

Data Descriptor: Daily observations of stable isotope ratios of rainfall in the tropics

Correction: CD95 maintains stem cell-like and non-classical EMT programs in primary human glioblastoma cells

Metabolic and physiological interdependencies in the Bathymodiolus azoricus symbiosis

Multiparametric high-resolution imaging of native proteins by force-distance curve–based AFM

Abdominal fat deposits determined by magnetic resonance imaging in relation to leptin and vaspin levels as well as insulin resistance in the general adult population

Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis

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