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Showing 1–16 of 16 results
Advanced filters: Author: Mostafa Bakhti Clear advanced filters

  • How pancreatic islets of Langerhans are built during development is incompletely understood. Here the authors find that Synaptotagmin-13 mediates remodeling of cell-matrix adhesion to regulate endocrine cell egression and islet morphogenesis.

    • Mostafa Bakhti
    • Aimée Bastidas-Ponce
    • Heiko Lickert
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Moscot is an optimal transport approach that overcomes current limitations of similar methods to enable multimodal, scalable and consistent single-cell analyses of datasets across spatial and temporal dimensions.

    • Dominik Klein
    • Giovanni Palla
    • Fabian J. Theis
    ResearchOpen Access
    Nature
    Volume: 638, P: 1065-1075

  • CellRank infers directed cell state transitions and cell fates incorporating RNA velocity information into a graph based Markov process.

    • Marius Lange
    • Volker Bergen
    • Fabian J. Theis
    ResearchOpen Access
    Nature Methods
    Volume: 19, P: 159-170

  • Beta cell subpopulations with low expression in PDX1, MAFA, and insulin might contribute to islet function and insulin release. Here the authors show that altering the proportion of PDX1LOW MAFALOW to PDX1HIGH MAFAHIGH cells impairs islet function.

    • Daniela Nasteska
    • Nicholas H. F. Fine
    • David J. Hodson
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19

  • β-cell dedifferentiation has emerged as a contributing mechanism in type 1 and type 2 diabetes development. Here Sachs et al. show that a pharmacological treatment that combines insulin and a GLP-1–oestrogen conjugate reverses dedifferentiation, and improves β-cell function and hyperglycaemia in diabetic mice.

    • Stephan Sachs
    • Aimée Bastidas-Ponce
    • Heiko Lickert
    Research
    Nature Metabolism
    Volume: 2, P: 192-209

  • Patients with severe diabetes rely on insulin injections to control their blood glucose. A study now provides evidence that human cells that normally do not release insulin can be converted into insulin-producing cells that are able to normalize glycaemia in diabetic mice.

    • Mostafa Bakhti
    • Heiko Lickert
    News & Views
    Nature Metabolism
    Volume: 1, P: 312-313

  • In 2021, several discoveries shed light on the pathomechanisms of β-cell failure during the initiation and progression of diabetes mellitus, and validated novel molecular targets for intervention. Moreover, the field of stem-cell-derived replacements for β-cells is rapidly advancing. These advances bring us closer to therapies to protect and/or regenerate β-cell mass.

    • Mostafa Bakhti
    • Heiko Lickert
    News & Views
    Nature Reviews Endocrinology
    Volume: 18, P: 79-80

  • Loss or dysfunction of β-cells is a characteristic of insulin-dependent diabetes mellitus. Regeneration of β-cells might stop or reverse the progression of the disease. This Review discusses the different modelling systems and technologies currently used to study β-cell biology in health and disease.

    • Mostafa Bakhti
    • Anika Böttcher
    • Heiko Lickert
    Reviews
    Nature Reviews Endocrinology
    Volume: 15, P: 155-171

  • Animal models are necessary for the discovery, validation and optimization of novel therapeutics. Here, Matthias Tschöp and colleagues consolidate the key information on the currently available animal models of obesity and diabetes mellitus and highlight the advantages, limitations and important caveats of each of these models.

    • Maximilian Kleinert
    • Christoffer Clemmensen
    • Matthias H. Tschöp
    Reviews
    Nature Reviews Endocrinology
    Volume: 14, P: 140-162