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Showing 1–3 of 3 results
Advanced filters: Author: Moxiao Li Clear advanced filters

  • This Review explores how cells sense and respond to mechanical signals across timescales. By integrating mechanosensing at membranes, mechanotransduction in the cytoplasm, and nuclear reprogramming, it reveals a role of temporal dynamics in tissue development and disease.

    • Bo Cheng
    • Moxiao Li
    • Feng Xu
    Reviews
    Nature Reviews Physics
    P: 1-24

  • We report microscale magnetically actuated, cell-laden hydrogels (μMACs) for investigating the strain-induced cell response in three-dimensional (3D) microenvironments. These μMACs provide high-throughput arrays of defined 3D cellular microenvironments that undergo reversible, relatively homogeneous deformation following non-contact actuation under external magnetic fields. Such technique not only enables the application of high strains (up to 60%) to cells but also enables simplified microscopic visualization of these specimens under tension. The μMACs offer insights for mechanotransduction and may also provide a view of how cells respond to extracellular matrix in 3D.

    • Yuhui Li
    • Guoyou Huang
    • Feng Xu
    ResearchOpen Access
    NPG Asia Materials
    Volume: 8, P: e238