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Showing 1–6 of 6 results
Advanced filters: Author: Munther Khamashta Clear advanced filters

  • Allocation of therapy for systemic lupus erythematosus (SLE) remains complex, as most drugs used to treat this disease are used off-label—a situation compounded by the emergence of new therapeutics. In this rapidly changing clinical setting, organ-specific therapeutic guidelines might be useful for 'real world' management of patients with SLE.

    • Manuel Ramos-Casals
    • Munther A. Khamashta
    News & Views
    Nature Reviews Rheumatology
    Volume: 8, P: 128-130

  • Autoimmune congenital heart block is more likely to occur in the babies of women with rheumatic diseases, particularly women seropositive for anti-Ro or anti-La autoantibodies. Here, the authors provide advice for the management of these women and their babies in juxtaposition to a systematic assessment of the epidemiology and classification of the disease.

    • Pilar Brito-Zerón
    • Peter M. Izmirly
    • Munther A. Khamashta
    Reviews
    Nature Reviews Rheumatology
    Volume: 11, P: 301-312

  • The range of clinical manifestations and autoantibodies that are recognized as important in antiphosphlipid syndrome (APS) is constantly increasing. How can disease manifestations and autoantibodies that fall outside of the classic APS criteria be incorporated into diagnosis in the future?

    • Savino Sciascia
    • Mary-Carmen Amigo
    • Munther Khamashta
    Reviews
    Nature Reviews Rheumatology
    Volume: 13, P: 548-560

  • Antiphospholipid syndrome, a disorder characterized by pregnancy morbidity and thrombosis in young individuals, is diagnosed by detection of anticardiolipin antibodies or lupus anticoagulant using laboratory tests. As discussed in this review, correct identification of patients with this syndrome is important as prophylactic anticoagulant therapy can prevent recurrent thrombosis and reduce complications during pregnancy.

    • Maria Laura Bertolaccini
    • Munther A Khamashta
    • Graham RV Hughes
    Reviews
    Nature Clinical Practice Rheumatology
    Volume: 1, P: 40-46

  • Antiphospholipid syndrome (APS) is an autoimmune disease characterized by antiphospholipid antibodies and thrombotic events. The kidney is a major target organ of APS, which is often present in association with other autoimmune disorders. In this Review, Sciascia et al. discuss the broadening spectrum of renal events associated with APS and the different therapeutic approaches that might be required for effective treatment.

    • Savino Sciascia
    • Maria José Cuadrado
    • Dario Roccatello
    Reviews
    Nature Reviews Nephrology
    Volume: 10, P: 279-289

  • Checkpoint inhibitors are increasingly being used in clinical practice; however, these therapies can be associated with adverse events that can affect almost any organ system. This Primer by Ramos-Casals and colleagues summarizes the epidemiology, mechanisms, diagnosis and treatment of these adverse events.

    • Manuel Ramos-Casals
    • Julie R. Brahmer
    • Maria E. Suárez-Almazor
    Reviews
    Nature Reviews Disease Primers
    Volume: 6, P: 1-21