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Showing 1–2 of 2 results
Advanced filters: Author: Murali Jayaraman Clear advanced filters

  • The huntingtin protein (HTT) contains a polyQ tract preceded by an N-terminal flanking sequence (HTTNT) that contributes to HTT aggregation. Now the role of HTTNT in aggregation is explored in vitro, revealing a complex, multistep pathway initiated when polyQ disrupts HTTNT structure, enhancing the latter's assembly into prefibrillar aggregates. Within these intermediates, subsequent interactions of the polyQ moieties drive further assembly into compact amyloid aggregates.

    • Ashwani K Thakur
    • Murali Jayaraman
    • Ronald Wetzel
    Research
    Nature Structural & Molecular Biology
    Volume: 16, P: 380-389

  • The formation of aggregates of polyglutamine (polyQ) sequences is initiated by nucleated growth polymerization. New results show that over a short repeat length range from Q26 to Q23 the size of the nucleus changes from monomeric to dimeric to tetrameric, suggesting aggregation nucleus size has a role in pathogenicity.

    • Karunakar Kar
    • Murali Jayaraman
    • Ronald Wetzel
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 328-336