Nature Search

Whole-genome sequencing in 333,100 individuals reveals rare non-coding single variant and aggregate associations with height

Here, the authors perform a rare-variant analysis of whole-genome sequence data that takes advantage of three global biobanks. They identify 29 novel rare variants associated with human height, and demonstrate an approach for identifying non-coding rare variants in regulatory regions with large effects from whole-genome sequencing data.

Gareth Hawkes
Robin N. Beaumont
Michael N. Weedon
ResearchOpen Access03 Oct 2024
Nature Communications

Volume: 15, P: 1-11
Whole-genome sequencing analysis identifies rare, large-effect noncoding variants and regulatory regions associated with circulating protein levels

Rare variant association analysis of plasma proteins using whole-genome sequencing data in 54,306 individuals in the UK Biobank demonstrates that combining both single-variant and aggregate testing will be needed for noncoding variant analysis.

Gareth Hawkes
Kartik Chundru
Robin N. Beaumont
ResearchOpen Access24 Feb 2025
Nature Genetics

Volume: 57, P: 626-634
Possible optical observation of the companion star to the binary pulsar PSR1913 + 16

Philippe Crane
Jerry E. Nelson
J. Anthony Tyson
Research01 Aug 1979
Nature

Volume: 280, P: 367-370
Lactose Flux Occurs by Differing Mechanisms in the Colon and Jejunum of Newborn Piglets

Robert D Murray
Anton H Ailabouni
Howard R Sloan
Research01 Jun 1993
Pediatric Research

Volume: 33, P: 568-572
Image distortion near galaxies: dwarfs or lensing?

J. Anthony Tyson
Research29 Aug 1985
Nature

Volume: 316, P: 799-800
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) is an anti-inflammatory drug proposed as a treatment for COVID19. Here the results are reported from a randomised trial testing DMF treatment in 713 patients hospitalised with COVID-19. DMF was not associated with any improvement in day 5 outcomes.

Peter Sandercock
Janet Darbyshire
Martin J. Landray
ResearchOpen Access31 Jan 2024
Nature Communications

Volume: 15, P: 1-13
European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation

The genetic basis of atopic dermatitis is not fully understood. Here, the authors find 91 genetic loci associated with atopic dermatitis in a GWAS of >1million individuals, which highlight the importance of systemic immune regulation.

Ashley Budu-Aggrey
Anna Kilanowski
Lavinia Paternoster
ResearchOpen Access04 Oct 2023
Nature Communications

Volume: 14, P: 1-18
Species-wide genomics of kākāpō provides tools to accelerate recovery

The kākāpō is an intensively managed parrot endemic to New Zealand. Using genome sequencing data for all living kākāpō together with long-term phenotypic data, the authors devise an approach to identify genetic associations with fitness traits, which is informing species recovery plans.

Joseph Guhlin
Marissa F. Le Lec
Peter K. Dearden
Research28 Aug 2023
Nature Ecology & Evolution

Volume: 7, P: 1693-1705
Dense sampling of bird diversity increases power of comparative genomics

A dataset of the genomes of 363 species from the Bird 10,000 Genomes Project shows increased power to detect shared and lineage-specific variation, demonstrating the importance of phylogenetically diverse taxon sampling in whole-genome sequencing.

Shaohong Feng
Josefin Stiller
Guojie Zhang
Research11 Nov 2020
Nature

Volume: 587, P: 252-257
Direct visuomotor transformations for reaching

Christopher A. Buneo
Murray R. Jarvis
Richard A. Andersen
Research11 Apr 2002
Nature

Volume: 416, P: 632-636
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
Author Correction: Dense sampling of bird diversity increases power of comparative genomics

Shaohong Feng
Josefin Stiller
Guojie Zhang
Amendments and CorrectionsOpen Access08 Apr 2021
Nature

Volume: 592, P: E24
Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis

Lavinia Paternoster and colleagues report a meta-analysis of genome-wide association studies of atopic dermatitis. They report three newly identified associated loci near OVOL1 and ACTL9 and in KIF3A.

Lavinia Paternoster
Marie Standl
Stephan Weidinger
Research25 Dec 2011
Nature Genetics

Volume: 44, P: 187-192
Observation of the rare B_s⁰ →µ⁺µ⁻ decay from the combined analysis of CMS and LHCb data

Combined analysis of proton-proton collision data from the Large Hadron Collider at CERN by the CMS and LHCb collaborations leads to the observation of the extremely rare decay of the strange B meson into muons; the result is compatible with the standard model of particle physics, and does not show any signs of new physics, such as supersymmetry.

V. Khachatryan
A.M. Sirunyan
E. Pesen
ResearchOpen Access13 May 2015
Nature

Volume: 522, P: 68-72
Association between antibody responses post-vaccination and severe COVID-19 outcomes in Scotland

Calum Macdonald
Norah Palmateer
Josie Murray
ResearchOpen Access14 Jun 2024
npj Vaccines

Volume: 9, P: 1-12

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