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Oncogenesis (2)
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Showing 1–4 of 4 results

Advanced filters: Author: Muzaffer Ahmad Kassab Clear advanced filters

NADP⁺ is an endogenous PARP inhibitor in DNA damage response and tumor suppression

Cancer cells respond differently to inhibitors of Poly (ADP-ribose) polymerase. Here the authors reveal that ovarian cancer cells with higher cellular NADP+ levels are more sensitive to clinically relevant PARP1 inhibitors and show that NADP+ act as an endogenous inhibitor of PARP enzymes.

Chunjing Bian
Chao Zhang
Xiaochun Yu
ResearchOpen Access11 Feb 2019
Nature Communications

Volume: 10, P: 1-14
PARP2 mediates branched poly ADP-ribosylation in response to DNA damage

PARP1 and PARP2 of the PARP family enzymes are involved in DNA damage response. Here the authors report PARP2 activation mechanisms and its role in the formation of branched poly(ADP-ribose) chains in response to DNA damage.

Qian Chen
Muzaffer Ahmad Kassab
Xiaochun Yu
ResearchOpen Access13 Aug 2018
Nature Communications

Volume: 9, P: 1-13
Correction: LGR5 regulates gastric adenocarcinoma cell proliferation and invasion via activating Wnt signaling pathway

Xiangfei Wang
Xiumin Wang
Chen Wu
Amendments and CorrectionsOpen Access02 Feb 2019
Oncogenesis

Volume: 8, P: 1
LGR5 regulates gastric adenocarcinoma cell proliferation and invasion via activating Wnt signaling pathway

Xiangfei Wang
Xiumin Wang
Chen Wu
ResearchOpen Access09 Aug 2018
Oncogenesis

Volume: 7, P: 1-14