Nature Search

CLADES: a hybrid NeuralODE-Gillespie approach for unveiling clonal cell fate and differentiation dynamics

Recent studies have traced haematopoiesis at the clonal level but lack a way to extract dynamical information. Here, authors develop CLADES, a tool to estimate cellular kinetics and the number of divisions to produce mature cells for each clone, in human cord blood and adult mouse haematopoiesis.

Mingze Gao
Melania Barile
Yuanhua Huang
ResearchOpen Access01 Sept 2025
Nature Communications

Volume: 16, P: 1-16
A subset of type-II collagen-binding antibodies prevents experimental arthritis by inhibiting FCGR3 signaling in neutrophils

Rheumatoid arthritis (RA) involves several types of autoantibodies, which are usually considered pathogenic. In this study, the authors use phage display to develop antibodies targeting type-II collagen that are protective in multiple experimental models of RA.

Zhongwei Xu
Bingze Xu
Rikard Holmdahl
ResearchOpen Access23 Sept 2023
Nature Communications

Volume: 14, P: 1-14
Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis

Using data from a single time point, passenger-approximated clonal expansion rate (PACER) estimates the fitness of common driver mutations that lead to clonal haematopoiesis and identifies TCL1A activation as a mediator of clonal expansion.

Joshua S. Weinstock
Jayakrishnan Gopakumar
Siddhartha Jaiswal
Research12 Apr 2023
Nature

Volume: 616, P: 755-763
The ATP-binding cassette transporter A1 regulates phosphoantigen release and Vγ9Vδ2 T cell activation by dendritic cells

γδT cells are activated by phosphoantigens, and ABCA1 is involved in cholesterol transport. Here the authors link these ideas to show that ABCA1, apoA-I and BTN3A1 regulate extracellular phosphoantigen release by dendritic cells, and implicate ABCA1 in mevalonate-mediated activation of Vγ9Vδ2 T cells.

Barbara Castella
Joanna Kopecka
Massimo Massaia
ResearchOpen Access05 Jun 2017
Nature Communications

Volume: 8, P: 1-14
HER2 expression identifies dynamic functional states within circulating breast cancer cells

Patient-derived circulating tumour cells are used to characterize the dynamics and underlying plasticity of HER2 expression in non-HER2-amplified breast tumours.

Nicole Vincent Jordan
Aditya Bardia
Daniel A. Haber
Research24 Aug 2016
Nature

Volume: 537, P: 102-106
Constitutive IP₃ signaling underlies the sensitivity of B-cell cancers to the Bcl-2/IP₃ receptor disruptor BIRD-2

Mart Bittremieux
Rita M. La Rovere
Geert Bultynck
ResearchOpen Access13 Jun 2018
Cell Death & Differentiation

Volume: 26, P: 531-547
Activity-induced MEMRI cannot detect functional brain anomalies in the APPxPS1-Ki mouse model of Alzheimer’s disease

Alexandre Androuin
Yah-se Abada
Benoît Delatour
ResearchOpen Access04 Feb 2019
Scientific Reports

Volume: 9, P: 1-8
Overproduction of Encapsulated Insecticidal Crystal Proteins in a Bacillus thuringiensis spoOA Mutant

Didier Lereclus
Hervé Agaisse
Josette Chaufaux
Research01 Jan 1995
Bio/Technology

Volume: 13, P: 67-71
Dual targeting of the DNA damage response pathway and BCL-2 in diffuse large B-cell lymphoma

Alessandra Rossi
Stefania Orecchioni
Enrico Derenzini
ResearchOpen Access24 Jul 2021
Leukemia

Volume: 36, P: 197-209
Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning

Jari Lahti
Samuli Tuominen
Katri Räikkönen
ResearchOpen Access16 Aug 2022
Molecular Psychiatry

Volume: 27, P: 4419-4431
Close inbreeding and low genetic diversity in Inner Asian human populations despite geographical exogamy

Nina Marchi
Philippe Mennecier
Evelyne Heyer
ResearchOpen Access20 Jun 2018
Scientific Reports

Volume: 8, P: 1-10

Search

CLADES: a hybrid NeuralODE-Gillespie approach for unveiling clonal cell fate and differentiation dynamics

A subset of type-II collagen-binding antibodies prevents experimental arthritis by inhibiting FCGR3 signaling in neutrophils

Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis

The ATP-binding cassette transporter A1 regulates phosphoantigen release and Vγ9Vδ2 T cell activation by dendritic cells

HER2 expression identifies dynamic functional states within circulating breast cancer cells

Constitutive IP₃ signaling underlies the sensitivity of B-cell cancers to the Bcl-2/IP₃ receptor disruptor BIRD-2

Activity-induced MEMRI cannot detect functional brain anomalies in the APPxPS1-Ki mouse model of Alzheimer’s disease

Overproduction of Encapsulated Insecticidal Crystal Proteins in a Bacillus thuringiensis spoOA Mutant

Dual targeting of the DNA damage response pathway and BCL-2 in diffuse large B-cell lymphoma

Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning

Close inbreeding and low genetic diversity in Inner Asian human populations despite geographical exogamy

Search

Quick links

Search

Filter By:

Search

Quick links